中国阜阳市新型独特重组（CRF01_AE/CRF07_BC）的全长基因组特征分析。
Near Full-Length Genomic Characterization of a Novel Unique Recombinant (CRF01_AE/CRF07_BC) in Fuyang City of China.
机构信息
Department of AIDS Research, State Key Laboratory of Pathogen and Biosecurity, Beijing Institute of Microbiology and Epidemiology, Beijing, China.
Department of AIDS Confirmation Laboratory, Anhui Provincial Center for Disease Control and Prevention, Hefei, China.
出版信息
AIDS Res Hum Retroviruses. 2020 Jun;36(6):527-532. doi: 10.1089/AID.2020.0002. Epub 2020 Apr 15.
Recombinant forms contribute substantially to the genetic diversity of HIV-1. Recent studies have also revealed that three major viral strains (CRF07_BC, CRF01_AE, and subtype B) have been cocirculating among men who have sex with men (MSM) in Anhui, suggesting a high probability of generating new recombinants. In this study, we reported a novel CRF01_AE and CRF07_BC HIV-1 recombinant form in MSM in Fuyang city of China. Two near full-length genome (NFLG) named FY184 and FY208 were successfully obtained. The genomic composition analysis of the NFLG reveals that it was divided into four segments by three breakpoints, with two regions of CRF07_BC inserted into a CRF01_AE backbone's gag and pol regions. The CRF01_AE regions were originated from a subcluster lineage of CRF01_AE, which is mainly circulating among MSM in China. The emergence of a novel recombinant of CRF01_AE/CRF07_BC is indicative of the increasing genetic diversity of the HIV epidemic in MSM in Anhui.
重组形式对 HIV-1 的遗传多样性有很大贡献。最近的研究还表明，三种主要病毒株（CRF07_BC、CRF01_AE 和亚型 B）一直在安徽的男男性行为者（MSM）中共同传播，这表明产生新重组体的可能性很高。在这项研究中，我们报告了在中国阜阳市 MSM 中出现的一种新型 CRF01_AE 和 CRF07_BC HIV-1 重组形式。成功获得了两个近乎全长基因组（NFLG），分别命名为 FY184 和 FY208。NFLG 的基因组组成分析表明，它通过三个断点分为四个区域，两个 CRF07_BC 区域插入到 CRF01_AE 主干的 gag 和 pol 区域。CRF01_AE 区域来源于 CRF01_AE 的一个亚群谱系，主要在中国的 MSM 中传播。新型 CRF01_AE/CRF07_BC 重组体的出现表明安徽 MSM 中 HIV 流行的遗传多样性不断增加。
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