Yamada T, Akiyama H, McGeer P L
University of British Columbia, Kinsmen Laboratory of Neurological Research, Department of Psychiatry, Vancouver, Canada.
Neurosci Lett. 1990 May 4;112(2-3):161-6. doi: 10.1016/0304-3940(90)90196-g.
Clusters of oligodendroglial fibers were identified immunohistochemically in human brain tissue with antibodies to the complement proteins C3d and C4d in several neurological disorders. These included Pick's, Huntington's, Parkinson's and Alzheimer's disease, amyotrophic lateral sclerosis, progressive supranuclear palsy and Shy-Drager syndrome. These complement-activated oligodendroglia occurred in selected areas of gray and white matter. They were rarely observed in control tissue. Immunogold electron microscopy established that the C4d antibody was attached to degenerating myelin sheaths. These data indicate attachment of classical complement pathway proteins to selective oligodendroglia in several neurological disorders.
在几种神经疾病中，利用针对补体蛋白C3d和C4d的抗体，通过免疫组织化学方法在人脑组织中鉴定出少突胶质纤维簇。这些疾病包括匹克氏病、亨廷顿氏病、帕金森氏病和阿尔茨海默病、肌萎缩侧索硬化症、进行性核上性麻痹和夏伊-德雷格综合征。这些补体激活的少突胶质细胞出现在灰质和白质的特定区域。在对照组织中很少观察到它们。免疫金电子显微镜证实C4d抗体附着在退化的髓鞘上。这些数据表明在几种神经疾病中经典补体途径蛋白附着于选择性少突胶质细胞。
