University of Pittsburgh School of Medicine, Division of Cardiology, Center for Metabolism and Mitochondrial Medicine and Vascular Medicine Institute, Pittsburgh, PA, United States.
Department of Pathology and Laboratory Medicine, Perelman School of Medicine University of Pennsylvania, Philadelphia, PA, United States.
Curr Med Chem. 2019;26(16):2918-2932. doi: 10.2174/0929867325666180228165527.
Some DNA or RNA sequences rich in guanine (G) nucleotides can adopt noncanonical conformations known as G-quadruplexes (G4). In the nuclear genome, G4 motifs have been associated with genome instability and gene expression defects, but they are increasingly recognized to be regulatory structures. Recent studies have revealed that G4 structures can form in the mitochondrial genome (mtDNA) and potential G4 forming sequences are associated with the origin of mtDNA deletions. However, little is known about the regulatory role of G4 structures in mitochondria. In this short review, we will explore the potential for G4 structures to regulate mitochondrial function, based on evidence from the nucleus.
富含鸟嘌呤（G）核苷酸的一些 DNA 或 RNA 序列可以采用称为 G-四链体（G4）的非经典构象。在核基因组中，G4 基序与基因组不稳定性和基因表达缺陷有关，但它们越来越被认为是调节结构。最近的研究表明，G4 结构可以在线粒体基因组（mtDNA）中形成，潜在的 G4 形成序列与 mtDNA 缺失的起源有关。然而，关于 G4 结构在线粒体中的调节作用知之甚少。在这篇简短的综述中，我们将根据核内的证据，探讨 G4 结构调节线粒体功能的潜力。
