Andrews Simon, Norton Ian, Salunkhe Arvindkumar S, Goodluck Helen, Aly Wafaa S M, Mourad-Agha Hanna, Cornelis Pierre
The School of Biological Sciences, The University of Reading, Whiteknights, Reading, RG6 6AJ, UK,
Met Ions Life Sci. 2013;12:203-39. doi: 10.1007/978-94-007-5561-1_7.
Bacteria depend upon iron as a vital cofactor that enables a wide range of key metabolic activities. Bacteria must therefore ensure a balanced supply of this essential metal. To do so, they invest considerable resourse into its acquisition and employ elaborate control mechanisms to eleviate both iron-induced toxitiy as well as iron deficiency. This chapter describes the processes that bacteria engage in maintaining iron homeostasis. The focus is Escherichia coli, as this bacterium provides a well studied example. A summary of the current status of understanding of iron management at the 'omics' level is also presented.
细菌依赖铁作为一种至关重要的辅助因子，它能促成广泛的关键代谢活动。因此，细菌必须确保这种必需金属的平衡供应。为此，它们投入大量资源用于获取铁，并采用复杂的控制机制来减轻铁诱导的毒性以及铁缺乏。本章描述了细菌维持铁稳态所涉及的过程。重点是大肠杆菌，因为这种细菌提供了一个研究充分的例子。还介绍了在“组学”水平上对铁管理理解的当前状况总结。
