Else Kröner-Fresenius-Center for Nutritional Medicine, Klinikum rechts der Isar, Technische Universität München, Munich, Germany.
Obesity (Silver Spring). 2014 Jan;22(1):217-24. doi: 10.1002/oby.20481. Epub 2013 Sep 10.
To investigate the effect of reducing the n-6/n-3 fatty acid ratio in maternal nutrition on the maternal and cord blood leptin axis and their association with infant body composition up to 2 years.
208 healthy pregnant women were randomized to either a dietary intervention to reduce the n-6/n-3 fatty acid ratio from 15th week of gestation until 4 months postpartum or a control group. Leptin, soluble leptin receptor and free leptin index were determined in maternal and cord plasma and related to infant body composition assessed by skinfold thicknesses up to 2 years.
The intervention had no effect on either the maternal or fetal leptin axis. Maternal leptin in late pregnancy was inversely related to infant weight and lean body mass (LBM) up to 2 years, after multiple adjustments. Cord leptin was positively related to weight, body fat, and LBM at birth, and inversely associated with weight, BMI, fat mass, and LBM at 2 years and weight gain up to 2 years. The contribution of cord leptin to infant outcomes was overall stronger compared with maternal leptin.
Both, maternal and fetal leptin were associated with subsequent infant anthropometry with a greater impact of fetal leptin.
探讨降低母体营养中 n-6/n-3 脂肪酸比例对母血和脐血瘦素轴的影响及其与婴儿体成分的关系，随访至 2 岁。
208 名健康孕妇被随机分为饮食干预组和对照组，从妊娠第 15 周到产后 4 个月，饮食干预组降低 n-6/n-3 脂肪酸比例，对照组不进行干预。测定母血和脐血中的瘦素、可溶性瘦素受体和游离瘦素指数，并与婴儿体成分（通过皮褶厚度评估）相关，随访至 2 岁。
干预对母血和胎血瘦素轴均无影响。孕晚期母血瘦素与婴儿体重和 2 岁时的瘦体质量（LBM）呈负相关，经多次调整后仍有相关性。脐血瘦素与出生时的体重、体脂肪和 LBM 呈正相关，与 2 岁时的体重、BMI、体脂肪和 LBM 以及 2 岁时的体重增加呈负相关。与母血瘦素相比，脐血瘦素对婴儿结局的贡献总体上更强。
母血和胎血瘦素均与婴儿的人体测量学指标相关，且胎血瘦素的影响更大。
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