Hauner H, Vollhardt C, Schneider K T M, Zimmermann A, Schuster T, Amann-Gassner U
Else Kroner-Fresenius-Center for Nutritional Medicine, Technical University Munich, Munich, Germany.
Ann Nutr Metab. 2009;54(2):97-103. doi: 10.1159/000209267. Epub 2009 Mar 19.
Recent observational studies suggest that mean birth weight and body fat growth in the first year of life have increased continuously over the last decades. Both elevated birth weight and early fat mass are potential risk factors for childhood obesity. Experimental and limited clinical data suggest that the dietary ratio of n-6 to n-3 fatty acids (FAs) during pregnancy is critical for early adipose tissue growth. The aim of this randomized controlled study is to examine the effect of the supplementation with n-3 long-chain polyunsaturated FAs and reduction in the n-6/n-3 ratio in the diet of pregnant women/breast-feeding mothers on adipose tissue growth in their newborns using various methods for the assessment of body fat mass. Measurement of skinfold thickness in the newborn is the primary outcome parameter. Two hundred and four pregnant women will be recruited before the 15th week of gestation and randomly assigned to either active intervention or an isocaloric control diet. This upcoming study will explore the potential of this dietary approach to limit early adipose tissue growth and may contribute to the development of a new strategy for the primary prevention of childhood obesity.
最近的观察性研究表明，在过去几十年里，出生体重均值和生命第一年的体脂增长持续上升。出生体重过高和早期脂肪量均是儿童肥胖的潜在风险因素。实验及有限的临床数据表明，孕期n-6与n-3脂肪酸（FAs）的饮食比例对早期脂肪组织生长至关重要。这项随机对照研究的目的是，通过各种评估体脂量的方法，研究孕妇/哺乳期母亲饮食中补充n-3长链多不饱和脂肪酸以及降低n-6/n-3比例对其新生儿脂肪组织生长的影响。测量新生儿的皮褶厚度是主要结局参数。将在妊娠第15周前招募204名孕妇，并随机分配至积极干预组或等热量对照饮食组。这项即将开展的研究将探索这种饮食方法限制早期脂肪组织生长的潜力，并可能有助于制定一项预防儿童肥胖的新策略。
