Center for Infection and Immunity, Columbia University, New York, New York, USA.
J Virol. 2013 Jun;87(12):7185-90. doi: 10.1128/JVI.00324-13. Epub 2013 Apr 17.
The recent identification of nonprimate hepaciviruses in dogs and then in horses prompted us to look for pegiviruses (GB virus-like viruses) in these species. Although none were detected in canines, we found widespread natural infection of horses by a novel pegivirus. Unique genomic features and phylogenetic analyses confirmed that the tentatively named equine pegivirus (EPgV) represents a novel species within the Pegivirus genus. We also determined that EPgV causes persistent viremia whereas its clinical significance is undetermined.
最近在狗和马中发现了非灵长类动物的庚型肝炎病毒,这促使我们在这些物种中寻找庚型肝炎病毒(类似于 GB 病毒)。虽然在犬科动物中没有检测到,但我们发现马中存在一种新型的庚型肝炎病毒广泛自然感染。独特的基因组特征和系统进化分析证实,暂定名为马属庚型肝炎病毒(EPgV)代表了 Pegivirus 属中的一个新种。我们还确定 EPgV 引起持续性病毒血症,但其临床意义尚未确定。