犬瘟热病毒与猴群中致命疫情有关，它很容易适应使用人类受体。
Canine distemper virus associated with a lethal outbreak in monkeys can readily adapt to use human receptors.
机构信息
Department of Virology 3, National Institute of Infectious Diseases, Tokyo, Japan.
出版信息
J Virol. 2013 Jun;87(12):7170-5. doi: 10.1128/JVI.03479-12. Epub 2013 Apr 17.
Abstract
A canine distemper virus (CDV) strain, CYN07-dV, associated with a lethal outbreak in monkeys, used human signaling lymphocyte activation molecule as a receptor only poorly but readily adapted to use it following a P541S substitution in the hemagglutinin protein. Since CYN07-dV had an intrinsic ability to use human nectin-4, the adapted virus became able to use both human immune and epithelial cell receptors, as well as monkey and canine ones, suggesting that CDV can potentially infect humans.
摘要
一株与猴致死性暴发相关的犬瘟热病毒（CDV）株 CYN07-dV，仅能微弱地使用人类信号淋巴细胞激活分子作为受体，但在血凝蛋白 P541S 取代后很容易适应使用该受体。由于 CYN07-dV 具有内在的使用人类 nectin-4 的能力，适应后的病毒能够使用人类免疫和上皮细胞受体，以及猴和犬的受体，表明 CDV 可能具有感染人类的潜力。
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