[有机氯与女性乳腺癌关系的病例对照研究]

[A case-control study on the relationship between organochlorine and female breast cancer].

作者信息

Zhang Hong, Liu Lan, Zhang Pengju, Zhao Yi, Wu Xuejie, Ni Wensi

机构信息

School of Public Health, Ningxia Medical University, Yinchuan 750004, China.

出版信息

Wei Sheng Yan Jiu. 2013 Jan;42(1):44-8.

PMID:23596706

Abstract

OBJECTIVE

To describe the serum organochlorines residues and explore the relationship between organochlorines exposure and the female breast cancer in Ningxia.

METHODS

1:1 matched case-control study based on 92 new diagnostic breast cancer patients and 92 patients without tumors from Ningxia medical university general hospital was designed. The risk factors of breast cancer were investigated by a questionnaire. GC-ECD was used to measure the serum level of organochlorines residues. The adjusted odds rations (OR) of organochlorines residues to breast cancer were evaluated by conditional Logistic regression model.

RESULTS

15 organochlorines residues could be detected in serum of cases and controls. The detecting rates of beta-HCH, delta-HCH, p,p'-DDE, PCB28 and PCB52 were higher than 90%. There were significant differences of serum level of beta-HCH, p,p'-DDE and PCB52 between cases and controls (P < 0.05). After adjusting confounding factors, serum beta-HCH, p,p'-DDE and PCB52 level were positively related to the risk of breast cancer (adjusted OR > 2, P < 0.05).

CONCLUSION

Organochlorines resides, including DDT, HCH and PCB, may increase women's risk of getting breast cancer.

摘要

目的

描述血清中有机氯残留情况，探讨宁夏地区有机氯暴露与女性乳腺癌之间的关系。

方法

以宁夏医科大学总医院92例新诊断的乳腺癌患者和92例非肿瘤患者为研究对象，设计1:1匹配的病例对照研究。通过问卷调查乳腺癌的危险因素。采用气相色谱 - 电子捕获检测器（GC - ECD）测定血清中有机氯残留水平。用条件Logistic回归模型评估有机氯残留与乳腺癌的校正比值比（OR）。

结果

病例组和对照组血清中可检测到15种有机氯残留。β - 六氯环己烷（β - HCH）、δ - 六氯环己烷（δ - HCH）、p,p'-二氯二苯二氯乙烯（p,p'-DDE）、多氯联苯28（PCB28）和多氯联苯52（PCB52）的检出率高于90%。病例组和对照组血清中β - HCH、p,p'-DDE和PCB52水平存在显著差异（P < 0.05）。校正混杂因素后，血清β - HCH、p,p'-DDE和PCB52水平与乳腺癌风险呈正相关（校正OR > 2，P < 0.05）。