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Food Chem Toxicol. 2013 Aug;58:141-8. doi: 10.1016/j.fct.2013.03.050. Epub 2013 Apr 15.
Upon analysis of chemically complex food matrices a forest of peaks is likely to be found. Identification of these peaks and concurrent determination of the toxicological relevance upon exposure is very time consuming, expensive and often requires animal studies. Recently, a safety assessment framework based on the Threshold of Toxicological Concern (TTC) was published to assess the safety of chemically complex matrices more efficiently. In this safety assessment framework, the toxicological relevance of exposure to unidentified substances in chemically complex food matrices can be related to the Cramer class III TTC threshold, currently set at 90 μg/day. However, possible additive or synergistic effects of combined exposure is not covered. The current evaluation describes the relevance of combined low dose exposure to unidentified substances in chemically complex food matrices. It is concluded that to some extent cumulative effects at exposure levels for each substance at or below the Cramer class III TTC threshold, being present in a complex mixture including food, might occur. However the health relevance of possible cumulative effects at this dose level is considered to be that low that a need for a correction factor to cover possible cumulative effects is very low to absent.
在分析化学结构复杂的食物基质时，很可能会发现一片峰林。鉴定这些峰并同时确定接触时的毒理学相关性非常耗时、昂贵，而且通常需要动物研究。最近，发布了一个基于毒理学关注阈值（TTC）的安全评估框架，以更有效地评估化学结构复杂基质的安全性。在这个安全评估框架中，可以将化学结构复杂食物基质中未鉴定物质的暴露毒理学相关性与 Cramer 分类 III TTC 阈值相关联，目前设定为 90 μg/天。然而，对于联合暴露的可能的相加或协同效应，该框架没有涵盖。目前的评估描述了化学结构复杂食物基质中联合低剂量暴露于未鉴定物质的相关性。结论是，在 Cramer 分类 III TTC 阈值或以下的暴露水平下，每种物质的单独暴露可能会在复杂混合物（包括食物）中发生累积效应。但是，在这个剂量水平下，可能的累积效应的健康相关性被认为非常低，因此不需要一个校正因子来覆盖可能的累积效应。
