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睾丸精原细胞瘤脊髓复发继发急性脊髓压迫

Acute cord compression secondary to spinal relapse of testicular seminomas.

作者信息

Ng Yau Hong, Ho Henry Sun Sien, Kumar Naresh Satyanarayan

机构信息

Department of Orthopaedic Surgery, National University Hospital, Singapore, Singapore.

出版信息

BMJ Case Rep. 2013 Apr 17;2013:bcr2013008863. doi: 10.1136/bcr-2013-008863.

DOI:10.1136/bcr-2013-008863
PMID:23598935
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3645404/
Abstract

This is the first-reported case of an isolated thoracic spine relapse of a stage 1 testicular seminoma more than 1 year after surgery and radiotherapy. We report a 38-year-old gentleman, who underwent radical orchidectomy and adjuvant retroperitoneal irradiation for a pure testicular seminoma, presenting with acute cord compression from an isolated T8 relapse 14 months after the index surgery. Decompressive laminectomy with instrumentation was performed with adjuvant chemoradiotherapy. The patient gained full neurological recovery and has remained disease-free for 4 years. Testicular seminomas rarely relapse in the spine after treatment with surgery and radiotherapy, and it is usually the lumbar spine that is involved. Spinal relapse also commonly presents with pain rather than acute cord compression. This case report discusses the unique behaviour of testicular seminomas and their presentation in vertebral relapse. We also present a summary of the available literature on isolated thoracic spine relapse of testicular seminomas.

摘要

这是首例报告的1期睾丸精原细胞瘤在手术和放疗1年多后出现孤立性胸椎复发的病例。我们报告一名38岁男性,他因单纯睾丸精原细胞瘤接受了根治性睾丸切除术和辅助性腹膜后照射,在初次手术后14个月因孤立性T8复发出现急性脊髓压迫。进行了减压椎板切除术并植入器械,并辅助放化疗。患者神经功能完全恢复,且已无病生存4年。睾丸精原细胞瘤在手术和放疗后很少在脊柱复发,且通常累及腰椎。脊柱复发也通常表现为疼痛而非急性脊髓压迫。本病例报告讨论了睾丸精原细胞瘤的独特表现及其在椎体复发中的情况。我们还总结了关于睾丸精原细胞瘤孤立性胸椎复发的现有文献。

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1
Acute cord compression secondary to spinal relapse of testicular seminomas.睾丸精原细胞瘤脊髓复发继发急性脊髓压迫
BMJ Case Rep. 2013 Apr 17;2013:bcr2013008863. doi: 10.1136/bcr-2013-008863.
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Primary Extramedullary, Extradural Cervical Spine Seminoma.原发于椎管外硬脊膜的颈段精原细胞瘤。
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Anticancer Res. 2016 Apr;36(4):2033-4.
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[Role of radiotherapy in stage I testicular seminomas: about 25 cases].放射治疗在Ⅰ期睾丸精原细胞瘤中的作用:约25例报告
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引用本文的文献

1
Primary Extramedullary, Extradural Cervical Spine Seminoma.原发于椎管外硬脊膜的颈段精原细胞瘤。
J Am Acad Orthop Surg Glob Res Rev. 2020 Jul;4(7):e1900177. doi: 10.5435/JAAOSGlobal-D-19-00177.

本文引用的文献

1
Bone metastases in germ cell tumor patients.生殖细胞肿瘤患者的骨转移。
J Cancer Res Clin Oncol. 2012 Jun;138(6):947-52. doi: 10.1007/s00432-012-1169-3. Epub 2012 Feb 21.
2
[A case of solitary bone metastasis of testicular seminoma 6 years post orchiectomy].[睾丸精原细胞瘤睾丸切除术后6年发生孤立性骨转移1例]
Hinyokika Kiyo. 2011 Sep;57(9):517-20.
3
Malignant spinal cord compression secondary to testicular seminoma at the time of initial presentation and at relapse while on surveillance.初次就诊时以及在监测期间复发时,睾丸精原细胞瘤继发恶性脊髓压迫。
Can Urol Assoc J. 2007 Mar;1(1):59-63. doi: 10.5489/cuaj.41.
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Long-term outcome of postorchiectomy surveillance for Stage I testicular seminoma.I期睾丸精原细胞瘤睾丸切除术后监测的长期结果
Int J Radiat Oncol Biol Phys. 2005 Mar 1;61(3):736-40. doi: 10.1016/j.ijrobp.2004.06.209.
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Para-aortic irradiation for stage I testicular seminoma: results of a prospective study in 675 patients. A trial of the German testicular cancer study group (GTCSG).I期睾丸精原细胞瘤的主动脉旁照射:675例患者的前瞻性研究结果。德国睾丸癌研究组(GTCSG)的一项试验。
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Short course para-aortic radiation for stage I seminoma of the testis.睾丸I期精原细胞瘤的短疗程腹主动脉旁放疗。
Int J Radiat Oncol Biol Phys. 2003 Dec 1;57(5):1304-9. doi: 10.1016/s0360-3016(03)00754-5.
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Testicular tumors; a clinicopathological study.睾丸肿瘤;一项临床病理研究。
Cancer. 1953 May;6(3):427-54. doi: 10.1002/1097-0142(195305)6:3<427::aid-cncr2820060302>3.0.co;2-u.
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Multicenter study evaluating a dual policy of postorchiectomy surveillance and selective adjuvant single-agent carboplatin for patients with clinical stage I seminoma.一项多中心研究,评估对临床I期精原细胞瘤患者采用睾丸切除术后监测与选择性辅助单药卡铂治疗的双重策略。
Ann Oncol. 2003 Jun;14(6):867-72. doi: 10.1093/annonc/mdg241.
9
Prognostic factors for relapse in stage I seminoma managed by surveillance: a pooled analysis.I期精原细胞瘤监测管理中复发的预后因素:一项汇总分析。
J Clin Oncol. 2002 Nov 15;20(22):4448-52. doi: 10.1200/JCO.2002.01.038.
10
Prognostic factors for relapse in stage I testicular seminoma treated with surveillance.I期睾丸精原细胞瘤监测治疗后复发的预后因素
J Urol. 1997 May;157(5):1705-9; discussion 1709-10.