Krain J, Dieckmann K P
Department of Urology, Free University of Berlin, Klinikum Steglitz, FRG.
Eur Urol. 1994;26(2):184-6. doi: 10.1159/000475373.
The problem of adequate management of testicular germ cell tumors in patients with AIDS is increasingly important, as reflected by the increasing number of reports on the unclear pathogenetic association of the two conditions. Two HIV-positive patients (32 and 39 years old) at CDC stages II and IIb with pure seminoma have been treated. Both patients initially underwent semicastration. One patient (tumor stage IIa) then had retroperitoneal radiotherapy, and the other (tumor stage IIc) four cycles of carboplatin therapy. They have had no relapse after 35 and 14 months, respectively, and there has been no progression in the HIV infection stage. Stage-oriented treatment for testicular germ-cell tumors can, in principle, be applied in patients with HIV infection. Radiotherapy and chemotherapy do not necessarily lead to a deterioration in the clinical state of health of the immune status of HIV-infected patients and carboplatin monotherapy is an effective treatment with few side effects in patients with metastatic seminoma.
随着关于这两种疾病病因关联不明的报告数量不断增加，艾滋病患者睾丸生殖细胞肿瘤的充分管理问题变得越来越重要。两名分别为32岁和39岁、处于疾病控制中心（CDC）II期和IIb期的HIV阳性纯精原细胞瘤患者已接受治疗。两名患者最初均接受了半侧睾丸切除术。其中一名患者（肿瘤IIa期）随后接受了腹膜后放疗，另一名患者（肿瘤IIc期）接受了四个周期的卡铂治疗。他们分别在35个月和14个月后未出现复发，且HIV感染阶段也没有进展。原则上，针对睾丸生殖细胞肿瘤的分期治疗可应用于HIV感染患者。放疗和化疗不一定会导致HIV感染患者免疫状态的临床健康状况恶化，卡铂单一疗法对转移性精原细胞瘤患者是一种有效的治疗方法，且副作用较少。
