Conway B, Halliday W C, Brunham R C
Department of Medicine, University of Manitoba, Winnipeg, Canada.
Rev Infect Dis. 1990 May-Jun;12(3):479-82. doi: 10.1093/clinids/12.3.479.
We present the case of a 26-year-old human immunodeficiency virus-seropositive man who developed progressive multifocal leukoencephalopathy as the initial manifestation of AIDS. He appears to have responded dramatically to therapy with 3'-azido-3'-deoxythymidine (AZT). His neurologic status deteriorated shortly after an AZT dose reduction. He has stabilized since resuming his previous AZT dose. Although it remains unclear whether AZT is useful in the treatment of JC virus infection, we think that all AIDS patients with progressive multifocal leukoencephalopathy should be offered treatment with AZT, especially in light of recent reports describing a possible potentiation of human immunodeficiency virus infection of the central nervous system in this setting.
我们报告一例26岁的人类免疫缺陷病毒血清阳性男性，其以进行性多灶性白质脑病作为艾滋病的首发表现。他似乎对3'-叠氮-3'-脱氧胸苷（AZT）治疗有显著反应。在AZT剂量减少后不久，他的神经状态恶化。自恢复之前的AZT剂量后，他的病情已稳定。虽然尚不清楚AZT是否对治疗JC病毒感染有用，但我们认为，所有患有进行性多灶性白质脑病的艾滋病患者都应接受AZT治疗，特别是鉴于最近有报道称在这种情况下可能会增强人类免疫缺陷病毒对中枢神经系统的感染。
