Eickhoff J H, Andersen J, Laybourn C
Department of Surgical Gastroenterology D, Gentofte Hospital, Copenhagen, Denmark.
Br J Surg. 1991 Nov;78(11):1358-61. doi: 10.1002/bjs.1800781129.
Several reports suggest that perioperative blood transfusion promotes recurrence and death after cancer surgery. We studied the effect of transfusion in 1599 patients who had mastectomy for carcinoma of the breast. In 228 transfused patients the disease recurred in 110 (48 per cent), compared with 647 (47 per cent) of 1371 non-transfused patients (P = 0.85). The 5-year recurrence-free survival rate was 0.54 in the transfused patients and 0.60 in the non-transfused group (P = 0.44). The transfused patients had a higher prevalence of risk factors than the non-transfused patients. Cox's multiple regression analysis confirmed that perioperative blood transfusion was of no importance. The study does not support the hypothesis that perioperative blood transfusion promotes recurrence after operation for breast cancer.
几份报告表明，围手术期输血会促使癌症手术后复发和死亡。我们研究了1599例行乳腺癌乳房切除术患者的输血影响。在228例接受输血的患者中，110例（48%）疾病复发，而1371例未输血患者中有647例（47%）复发（P = 0.85）。输血患者的5年无复发生存率为0.54，未输血组为0.60（P = 0.44）。输血患者的危险因素患病率高于未输血患者。考克斯多元回归分析证实围手术期输血并不重要。该研究不支持围手术期输血会促使乳腺癌手术后复发这一假说。
