Axelson J, Håkanson R, Ihse I, Lilja I, Rehfeld J F, Sundler F
Dept. of Surgery, University of Lund, Sweden.
Scand J Gastroenterol. 1990 May;25(5):471-80. doi: 10.3109/00365529009095518.
Continuous subcutaneous infusion of cholecystokinin (CCK-8; 5 micrograms/kg/h) to rats for 7 weeks raised the plasma CCK concentration almost fivefold and increased the pancreatic weight by about 50% but was without effect on the gastrointestinal tract. Continuous subcutaneous infusion of the CCK antagonist L-364,718 (200 micrograms/kg/h) for 7 weeks reduced the weight of the pancreas by about 30% but was without effect on the gastrointestinal tract. The effect of continuous subcutaneous infusion of CCK-8 and L-364,718 in combination was very similar to that of L-364,718 alone. Pancreaticobiliary diversion (PBD) induced a nearly 10-fold increase in the plasma CCK concentration 3 and 7 weeks after the operation. The serum gastrin values were unaffected. The weight of the pancreas was more than doubled after 7 weeks. At the same time the small intestine had gained weight, but the colon was unaffected. Continuous subcutaneous infusion of L-364,718 prevented the effect of PBD on the pancreas. On the basis of the assumption that L-364,718 is a specific antagonist of CCK, we conclude that endogenous CCK has a trophic effect on the pancreas but not on the gastrointestinal tract and that it is essential for normal pancreatic growth.
对大鼠连续7周皮下输注胆囊收缩素（CCK - 8；5微克/千克/小时），可使血浆CCK浓度升高近5倍，胰腺重量增加约50%，但对胃肠道无影响。连续7周皮下输注CCK拮抗剂L - 364,718（200微克/千克/小时）可使胰腺重量减轻约30%，但对胃肠道无影响。连续皮下联合输注CCK - 8和L - 364,718的效果与单独输注L - 364,718非常相似。胰胆管改道术（PBD）在术后3周和7周可使血浆CCK浓度升高近10倍。血清胃泌素值未受影响。7周后胰腺重量增加了一倍多。与此同时，小肠重量增加，但结肠未受影响。连续皮下输注L - 364,718可防止PBD对胰腺的影响。基于L - 364,718是CCK特异性拮抗剂这一假设，我们得出结论：内源性CCK对胰腺有营养作用，但对胃肠道无此作用，且它对胰腺的正常生长至关重要。
