Xiao Ruo-Zhi, Long Zi-Jie, Xiong Mu-Jun, Wang Wen-Wen, Lin Dong-Jun
Department of Hematology, Third Affiliated Hospital, Sun Yat-sen University, Guangzhou, P.R. China ; ; Sun Yat-sen Institute of Hematology, Sun Yat-sen University, Guangzhou, P.R. China.
Oncol Lett. 2013 Apr;5(4):1229-1232. doi: 10.3892/ol.2013.1203. Epub 2013 Feb 19.
A previously healthy 34-year-old female presented with a 5-month history of progressive backache and weakness in the left fingers. Magnetic resonance imaging (MRI) showed soft tissue masses in the spinal canal distributed along the nerve course. The patient's baseline laboratory data were normal. Surgical intervention was performed and histological examination identified isolated spinal granulocytic sarcoma (GS). A bone marrow biopsy also presented normal findings. However, the patient developed numbness and pain in the right lower limb two months later. Fluorodeoxyglucose (FDG)-positron emission tomography (PET) showed FDG uptake in the left trapezius muscle, cervix uteri, iliac bone, lymphadenectasis of the pelvic wall and left axillary fossa. Cerebrospinal fluid (CSF) examination allowed a diagnosis of central nervous system leukemia (CNSL). The patient underwent chemotherapy and intrathecal injection, resulting in the elimination of the residual lesion. Correct diagnosis and adequate treatment are essential to achieve optimal results in patients with isolated spinal GS.
一名34岁既往健康的女性，出现了5个月的进行性背痛和左手手指无力症状。磁共振成像（MRI）显示椎管内沿神经走行分布的软组织肿块。患者的基线实验室数据正常。进行了手术干预，组织学检查确诊为孤立性脊柱粒细胞肉瘤（GS）。骨髓活检结果也正常。然而，两个月后患者出现右下肢麻木和疼痛。氟脱氧葡萄糖（FDG）-正电子发射断层扫描（PET）显示左侧斜方肌、子宫颈、髂骨、盆腔壁和左腋窝淋巴结转移灶有FDG摄取。脑脊液（CSF）检查确诊为中枢神经系统白血病（CNSL）。患者接受了化疗和鞘内注射，残余病灶得以消除。对于孤立性脊柱GS患者，正确诊断和充分治疗对于取得最佳疗效至关重要。
