Chang Rui, You Jiacong, Zhou Qinghua
Tianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute,Tianjin Medical University General Hospital, Tianjin 300052, China.
Zhongguo Fei Ai Za Zhi. 2013 Apr;16(4):211-5. doi: 10.3779/j.issn.1009-3419.2013.04.07.
Lung cancer is one of the most common diseases that endanger health and life of people domestically. A number of recurrence and death of lung cancer originated from metastasis. As a key step in metastasis of lung cancer, epithelial to mesenchymal transition involved down-regulation of E-cadherin, as well as regulated by EMT transcription factors. HATs and HDACs is a protein family that catalyzes acetylation and deacetylation of histones. Not only they have vital functions in tumor pathogenesis, but also participate in the EMT of lung cancer. HATs and HDACs interact with certain EMT transcription factors. Moreover, the function of these EMT transcription factors may be regulated by acetylation, which has influence on EMT program in lung cancer. Therefore, this review introduces the event of HATs and HDACs function in EMT of lung cancer, and investigate the molecular mechanism of their interaction. Then, the potential of HDAC inhibitor utilization in the inhibition of EMT and lung cancer therapy were discussed, as to pave the way for the related basic research and clinical practice.
肺癌是国内危害人们健康和生命的最常见疾病之一。肺癌的一些复发和死亡源于转移。作为肺癌转移的关键步骤，上皮-间质转化涉及E-钙黏蛋白的下调，并受EMT转录因子调控。组蛋白乙酰转移酶（HATs）和组蛋白去乙酰化酶（HDACs）是催化组蛋白乙酰化和去乙酰化的蛋白质家族。它们不仅在肿瘤发病机制中具有重要作用，还参与肺癌的上皮-间质转化。HATs和HDACs与某些EMT转录因子相互作用。此外，这些EMT转录因子的功能可能受乙酰化调节，这对肺癌的EMT程序有影响。因此，本综述介绍了HATs和HDACs在肺癌上皮-间质转化中的作用，并探讨了它们相互作用的分子机制。然后，讨论了HDAC抑制剂在抑制上皮-间质转化和肺癌治疗中的应用潜力，为相关基础研究和临床实践铺平道路。
