Zhang Yan-qing, Qian Jiang, Yuan Yi-fei, Xue Kang, Guo Jie, Wang Xiang-ning
Department of Ophthalmology, Eye and ENT Hospital of Fudan University, Shanghai 200031, China.
Zhonghua Yan Ke Za Zhi. 2013 Jan;49(1):27-31.
To study the change of tear film and lacrimal secretion after lacrimal gland tumor removal operation.
It was a retrospective case series study. Nineteen cases (19 eyes) with pleomorphic adenoma of the lacrimal gland from January, 2010 to July, 2011 in Eye and ENT Hospital of Fudan University were elected. The evaluation included subjective complaints of dry eye, tear break up time (BUT), reflex lacrimal secretion, corneal fluorescein staining, and size of lacrimal lake were analyzed before surgery and 3 days, 1 month and 6 months postoperatively. Simultaneously, the opposite eye was set as control.
Subjective complaints of dry eye increased and the mean tear break up time, reflex lacrimal secretion, and size of lacrimal lake were significantly reduced (t = 23.91, 16.90, 11.47; t = 19.31, 20.81, 11.95, P < 0.05) on day 3 and 1 month after operation which were (4.9 ± 2.0) s (3 d), (5.2 ± 1.6) s (1 moth); (4.05 ± 2.07) mm (3 d), (3.58 ± 1.98) mm (1 moth); (0.009 ± 0.004) mm(2) (3 d), (0.008 ± 0.003) mm(2)(1 moth) respectively. However, only reflex secretion test (3.53 ± 1.50 mm) was significantly reduced (t = 21.57, P < 0.05), other values (BUT: 17.4 ± 4.9 s, size of lake: 0.032 ± 0.005 mm(2)) recovered to preoperative levels by the time of the sixth month follow up visit. Corneal fluorescein staining score increased greatly when measured at day 3 and 1 month visit (t = 0.23, 1.69, P < 0.05), but had returned to preoperative values at the sixth month visit. The result of the opposite eye control is the same as preoperative control.
During the early stage after lacrimal gland tumor removal, tear film present abnormal changes, mainly in tear stability and reduction of reflex lacrimal secretion.
研究泪腺肿瘤切除术后泪膜及泪液分泌的变化。
这是一项回顾性病例系列研究。选取2010年1月至2011年7月在复旦大学附属眼耳鼻喉科医院就诊的19例（19眼）泪腺多形性腺瘤患者。评估内容包括干眼的主观症状、泪膜破裂时间（BUT）、反射性泪液分泌、角膜荧光素染色，并分析术前及术后3天、1个月和6个月时泪湖大小。同时，将对侧眼设为对照。
术后3天和1个月时，干眼主观症状增加，平均泪膜破裂时间、反射性泪液分泌及泪湖大小显著降低（t分别为23.91、16.90、11.47；t分别为19.31、20.81、11.95，P<0.05），具体数值分别为（4.9±2.0）秒（3天）、（5.2±1.6）秒（1个月）；（4.05±2.07）毫米（3天）、（3.58±1.98）毫米（1个月）；（0.009±0.004）平方毫米（3天）、（0.008±0.003）平方毫米（1个月）。然而，仅反射性分泌试验（3.53±1.50毫米）显著降低（t = 21.57，P<0.05），其他指标（BUT：17.4±4.9秒，泪湖大小：±0.032±0.005平方毫米）在随访第6个月时恢复至术前水平。角膜荧光素染色评分在术后3天和1个月时显著升高（t分别为0.23、1.69，P<0.05），但在第6个月时恢复至术前值。对侧眼对照结果与术前对照相同。
泪腺肿瘤切除术后早期，泪膜出现异常变化，主要表现为泪膜稳定性及反射性泪液分泌减少。
