Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Río Hortega, University of Valladolid, Valladolid, Spain.
Med Clin (Barc). 2013 Sep 7;141(5):189-93. doi: 10.1016/j.medcli.2012.12.021. Epub 2013 Apr 17.
The aim of our study was to investigate the influence of G-308 promoter variant of the tumor necrosis factor (TNF) alpha gene on metabolic changes and weight loss secondary to a high monounsaturated fat vs a high polyunsaturated fat hypocaloric diet in obese subjects.
A sample of 261 obese subjects were enrolled in a consecutive prospective way, from May 2011 to July 2012 in a tertiary hospital. In the basal visit, patients were randomly allocated during 3 months to Diet M (high monounsaturated fat hypocaloric diet) and Diet P (high polyunsaturated fat hypocaloric diet).
One hundred and ninety seven patients (73.2%) had the genotype G-308G and 64 (26.8%) patients had the genotype G-308A. There were no significant differences between the effects (on weight, body mass index (BMI), waist circumference, fat mass) in either genotype group with both diets. With the diet type P and in genotype G-308G, glucose levels (-6.7(22.1)mg/dl vs -3.7(2.2)mg/dl: p = 0.02), HOMA-R (-0.6(2.1)units vs -0.26(3.1)units: p = 0.01), insulin levels (-1.7(6.6)UI/L vs -0.6(7.1)UI/L: p = 0.009), total cholesterol levels (-15.3(31.1)mg/dl vs -8.4(22.1)mg/dl: p = 0.01), LDL cholesterol levels (-10.7(28.1)mg/dl vs -3.8(21.1)mg/dl: p = 0.008) and triglycerides (-12.1(52.1)mg/dl vs -6.6(43.1)mg/dl: p = 0.02) decreased.
Carriers of the G-308G promoter variant of TNF alpha gene have a better metabolic response than A-308 obese with a high polyunsaturated fat hypocaloric diet.
本研究旨在探讨肿瘤坏死因子（TNF）α基因 G-308 启动子变异对肥胖患者高单不饱和脂肪与高多不饱和脂肪低热量饮食继发代谢变化和体重减轻的影响。
2011 年 5 月至 2012 年 7 月，我们连续前瞻性纳入了一家三级医院的 261 名肥胖患者。在基线访视时，患者在 3 个月内随机分配至饮食 M（高单不饱和脂肪低热量饮食）和饮食 P（高多不饱和脂肪低热量饮食）。
197 名患者（73.2%）携带 G-308G 基因型，64 名患者（26.8%）携带 G-308A 基因型。在两种饮食下，两种基因型组的体重、体重指数（BMI）、腰围、体脂的影响均无显著差异。饮食 P 类型与 G-308G 基因型时，血糖水平（-6.7（22.1）mg/dl 与-3.7（2.2）mg/dl：p=0.02）、HOMA-R（-0.6（2.1）单位与-0.26（3.1）单位：p=0.01）、胰岛素水平（-1.7（6.6）UI/L 与-0.6（7.1）UI/L：p=0.009）、总胆固醇水平（-15.3（31.1）mg/dl 与-8.4（22.1）mg/dl：p=0.01）、LDL 胆固醇水平（-10.7（28.1）mg/dl 与-3.8（21.1）mg/dl：p=0.008）和甘油三酯水平（-12.1（52.1）mg/dl 与-6.6（43.1）mg/dl：p=0.02）均降低。
携带 TNFα 基因 G-308G 启动子变异的患者在接受高多不饱和脂肪低热量饮食时，其代谢反应优于 A-308 肥胖患者。
