Key Laboratory of Photochemical Conversion and Optoelectronic Materials, Technical Institute of Physics and Chemistry, CAS, Beijing 100190, PR China.
Anal Chim Acta. 2013 May 2;775:93-9. doi: 10.1016/j.aca.2013.03.013. Epub 2013 Mar 13.
A BODIPY(4,4-difluoro-4-bora-3a,4a-diaza-s-indacene)-based fluorometric sensor array has been developed for the highly sensitive detection of eight heavy-metal ions at micromolar concentration. The di-2-picolyamine (DPA) derivatives combine high affinities for a variety of heavy-metal ions with the capacity to perturb the fluorescence properties of BODIPY, making them perfectly suitable for the design of fluorometric sensor arrays for heavy-metal ions. 12 cross-reactive BODIPY fluorescent indicators provide facile identification of the heavy-metal ions using a standard chemometric approach (hierarchical clustering analysis); no misclassifications were found over 45 trials. Clear differentiation among heavy-metal ions as a function of concentration was also achieved, even down to 10(-7)M. A semi-quantitative interpolation of the heavy-metal concentration is obtained by comparing the total Euclidean distance of the measurement with a set of known concentrations in the library.
一种基于 BODIPY（4,4-二氟-4-硼-3a,4a-二氮杂-s-茚）的荧光传感器阵列已被开发出来，用于高灵敏度地检测八种重金属离子在微摩尔浓度。二-2-吡啶基胺（DPA）衍生物结合了对各种重金属离子的高亲和力，以及对 BODIPY 荧光性质的干扰能力，使它们非常适合设计用于重金属离子的荧光传感器阵列。12 个交叉反应的 BODIPY 荧光指示剂使用标准化学计量学方法（层次聚类分析）轻松识别重金属离子；在 45 次试验中没有发现错误分类。即使在 10（-7）M 时，也可以根据浓度清楚地区分重金属离子。通过将测量的总欧几里得距离与库中一组已知浓度进行比较，可对重金属浓度进行半定量内插。
