Department of Physiology, University of Pennsylvania, School of Medicine, Philadelphia, PA 19104, USA.
Respir Physiol Neurobiol. 2013 Jul 1;187(3):224-33. doi: 10.1016/j.resp.2013.04.006. Epub 2013 Apr 17.
The Coburn-Forster-Kane equation (CFKE) describes physiological variables that define pulmonary carbon monoxide (CO) uptake and excretion, and carboxyhemoglobin (COHb) levels. This equation is useful in predicting CO uptakes and COHb values in normal humans. However, some assumptions made in its derivation have never been proven and whether or not it accurately describes the physiology of CO excretion is not known. Two assumptions specifically addressed are: that the mean capillary PCO can be computed using the Haldane equation; and that the diffusing capacity relevant to CO uptake is equal to the diffusing capacity relevant to CO excretion. Both assumptions were supported by results obtained in this study. These findings plus results of experiments that compared measured and CFKE-calculated changes in the body CO stores suggest that the CFKE accurately describes the physiology of both pulmonary CO excretion and uptake.
科本-福斯特-凯恩方程（CFKE）描述了定义肺一氧化碳（CO）摄取和排泄以及碳氧血红蛋白（COHb）水平的生理变量。该方程可用于预测正常人体中的 CO 摄取量和 COHb 值。然而，其推导中所做的一些假设从未得到证实，也不知道它是否准确地描述了 CO 排泄的生理学。具体讨论了两个假设：一是可以使用亨德森方程计算平均毛细血管 PCO；二是与 CO 摄取相关的弥散能力等于与 CO 排泄相关的弥散能力。本研究结果均支持这两个假设。这些发现以及比较测量值和 CFKE 计算值的实验结果表明，CFKE 准确地描述了肺 CO 排泄和摄取的生理学。
