Peterson J E, Stewart R D
J Appl Physiol. 1975 Oct;39(4):633-8. doi: 10.1152/jappl.1975.39.4.633.
Data from a series of human exposures to carbon monoxide (CO) were analyzed to determine the fit to the theoretical Coburn-Forster-Kane (CFK) equation which describes CO absorption and excretion. The equation was found to predict carboxyhemoglobin (HbCO) saturations for both men and women at exercise rates ranging from sedentary to 300 kpm/min when they were exposed to steady CO concentrations of 50, 100, and 200 ppm for 0.33-5.25 h. Methods for determining values of each of the variables in the CFK equation were collected and a rational, efficient procedure for solving the equation by trial and error was outlined. The CFK equation was then used to prepare a graph, relating HbCO saturation to exposure duration and concentration, and also to describe the effect of several variables on the rate of CO uptake and equilibrium HbCO levels, important considerations in the determination of permissible public, occupational, and experimental exposure to CO.
分析了一系列人体一氧化碳（CO）暴露的数据，以确定其与描述CO吸收和排泄的理论科伯恩-福斯特-凯恩（CFK）方程的拟合情况。结果发现，当男性和女性在0.33 - 5.25小时内暴露于50、100和200 ppm的稳定CO浓度下，该方程能够预测从久坐到300 kpm/分钟运动速率下的碳氧血红蛋白（HbCO）饱和度。收集了确定CFK方程中每个变量值的方法，并概述了一种通过试错法求解该方程的合理、有效程序。然后使用CFK方程绘制了一张图表，将HbCO饱和度与暴露持续时间和浓度联系起来，还描述了几个变量对CO摄取速率和平衡HbCO水平的影响，这是确定公众、职业和实验中允许的CO暴露时的重要考虑因素。
