链霉菌中 AdpA 对抗生素下调因子 WblA 的抑制作用。
Repression of antibiotic downregulator WblA by AdpA in Streptomyces coelicolor.
机构信息
Department of Biological Engineering, Inha University, Incheon, Republic of Korea.
出版信息
Appl Environ Microbiol. 2013 Jul;79(13):4159-63. doi: 10.1128/AEM.00546-13. Epub 2013 Apr 19.
Abstract
The upstream region of antibiotic downregulatory wblA in Streptomyces coelicolor was found to contain AdpA binding motifs. A key morphological regulator, AdpA was shown to specifically bind these motifs by electrophoretic mobility shift assay. An adpA disruption mutant exhibited increased wblA transcription, suggesting that AdpA negatively regulates wblA transcription in S. coelicolor.
摘要
链霉菌中抗生素下调基因 wblA 的上游区域被发现含有 AdpA 结合基序。电泳迁移率变动分析显示，关键形态调控因子 AdpA 特异性结合这些基序。adpA 缺失突变体表现出 wblA 转录增加，表明 AdpA 负调控链霉菌中 wblA 的转录。
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