Wang Qing, Young Jim, Bernasconi Enos, Cavassini Matthias, Vernazza Pietro, Hirschel Bernard, Weber Rainer, Furrer Hansjakob, Stoeckle Marcel, Bucher Heiner C, Fux Christoph
Basel Institute for Clinical Epidemiology and Biostatistics, University Hospital Basel, Basel, Switzerland.
Antivir Ther. 2013;18(3):337-44. doi: 10.3851/IMP2372. Epub 2012 Sep 12.
Here, we aimed to determine the prevalence of erectile dysfunction (ED) among HIV-infected men and its association with components of antiretroviral therapy.
Cross-sectional data on sexual dysfunction were collected in the Swiss HIV Cohort Study (SHCS) between December 2009 and November 2010. Multilevel logistic regression models were used to estimate the association between ED and exposure to 24 different antiretroviral drugs from four drug classes.
During the study period, 5,194 of 5,539 eligible men in the SHCS had a follow-up visit; 4,064 men answered a question on ED for the first time. Among these men, ED was experienced often by 459 (11%), sometimes by 543 (13%), rarely by 389 (10%), never by 2,526 (62%) and 147 (4%) did not know. ED was associated with older age, an earlier HIV diagnosis and depression. No association was found with any drug class; however, ED was associated with cumulative exposure to either zalcitabine (OR 1.29 per year of use; 95% CI 1.07, 1.55) or enfuvirtide (OR 1.28; 95% CI 1.08, 1.52).
Around 1 in 10 men in the SHCS reported often experiencing ED. We found no association between ED and any drug class, but those exposed to zalcitabine or enfurvitide (drugs no longer or rarely used) were more likely to report ED; this second association was probably not causal.
在此，我们旨在确定感染艾滋病毒的男性中勃起功能障碍（ED）的患病率及其与抗逆转录病毒治疗各成分之间的关联。
2009年12月至2010年11月期间，在瑞士艾滋病毒队列研究（SHCS）中收集了性功能障碍的横断面数据。使用多水平逻辑回归模型来估计ED与来自四类药物的24种不同抗逆转录病毒药物暴露之间的关联。
在研究期间，SHCS中5539名符合条件的男性中有5194人进行了随访；4064名男性首次回答了有关ED的问题。在这些男性中，经常经历ED的有459人（11%），有时经历的有543人（13%），很少经历的有389人（10%），从未经历的有2526人（62%），147人（4%）表示不知道。ED与年龄较大、艾滋病毒诊断较早和抑郁症有关。未发现与任何药物类别有关联；然而，ED与齐多夫定（每年使用的比值比为1.29；95%置信区间为1.07，1.55）或恩夫韦肽（比值比为1.28；95%置信区间为1.08，1.52）的累积暴露有关。
SHCS中约十分之一的男性报告经常经历ED。我们发现ED与任何药物类别之间均无关联，但那些暴露于齐多夫定或恩夫韦肽（不再使用或很少使用的药物）的人更有可能报告ED；这第二种关联可能并非因果关系。
