Department of Bioresources, Fraunhofer Institute of Molecular Biology and Applied Ecology, Winchester Str. 2, 35395, Giessen, Germany.
Adv Biochem Eng Biotechnol. 2013;135:63-77. doi: 10.1007/10_2013_193.
: Average human life expectancy is increasing and so is the impact on society of aging and age-related diseases. Here we highlight recent advances in the diverse and multidisciplinary field of aging research, focusing on the fruit fly Drosophila melanogaster, an excellent model system in which to dissect the genetic and molecular basis of the aging processes. The conservation of human disease genes in D. melanogaster allows the functional analysis of orthologues implicated in human aging and age-related diseases. D. melanogaster models have been developed for a variety of age-related processes and disorders, including stem cell decline, Alzheimer's disease, and cardiovascular deterioration. Understanding the detailed molecular events involved in normal aging and age-related diseases could facilitate the development of strategies and treatments that reduce their impact, thus improving human health and increasing longevity.
人类的平均预期寿命正在延长，老龄化和与年龄相关的疾病对社会的影响也在增大。在这里，我们重点介绍了衰老研究这一多学科领域的最新进展，该研究聚焦于黑腹果蝇 Drosophila melanogaster，这是一个极好的模型系统，可用于剖析衰老过程的遗传和分子基础。人类疾病基因在黑腹果蝇中的保守性使得对与人类衰老和与年龄相关的疾病相关的同源基因的功能分析成为可能。已经开发出了多种与衰老相关的过程和疾病的黑腹果蝇模型，包括干细胞衰退、阿尔茨海默病和心血管恶化。了解正常衰老和与年龄相关的疾病中涉及的详细分子事件，有助于制定减轻其影响的策略和治疗方法，从而改善人类健康并延长寿命。
