Lepperdinger Guenter, Berger Peter, Breitenbach Michael, Frohlich Kai-Uwe, Grillari Johannes, Grubeck-Loebenstein Beatrix, Madeo Frank, Minois Nadege, Zwerschke Werner, Jansen-Durr Pidder
Department of Extracellular Matrix Research, Institute for Biomedical Aging Research, Austria Academy of Sciences, Rennweg 10, 6020 Innsbruck, Austria.
Front Biosci. 2008 May 1;13:7022-31. doi: 10.2741/3207.
A major goal in the field of aging research is to identify molecular mechanisms of aging at the cellular level, which are anticipated to form the basis for the development of age-associated dysfunctions and diseases in human beings. Recent progress in research into model organisms of aging has allowed determining precise molecular mechanisms and genetic determinants of the aging process, which appear to be conserved in evolution and some of which apply to human aging as well. The consortium of the authors focuses on aging mechanisms at the cellular level, and exploits the potential of genetic analyses in lower eukaryotic model organisms for a better understanding of regulatory pathways implicated in aging processes. We have established a new database (GiSAO), which provides a unique resource for the analysis of genome-wide expression patterns as being regulated by senescence, apoptosis and oxidative stress in our model systems. This has led to the identification of candidate genes, which are being tested for their impact on lifespan regulation in yeast, the fruit fly Drosophila melanogaster and the nematode C. elegans.
衰老研究领域的一个主要目标是在细胞水平上确定衰老的分子机制，预计这些机制将成为人类与年龄相关的功能障碍和疾病发展的基础。衰老模式生物研究的最新进展使得确定衰老过程精确的分子机制和遗传决定因素成为可能，这些机制在进化过程中似乎是保守的，其中一些也适用于人类衰老。本文作者团队专注于细胞水平的衰老机制，并利用低等真核模式生物的遗传分析潜力，以更好地理解衰老过程中涉及的调控途径。我们建立了一个新的数据库（GiSAO），它为分析我们模型系统中由衰老、凋亡和氧化应激调控的全基因组表达模式提供了独特的资源。这导致了候选基因的鉴定，目前正在测试这些基因对酵母、果蝇和线虫寿命调控的影响。
