Perrimon Norbert, Bonini Nancy M, Dhillon Paraminder
Department of Genetics, Harvard Medical School, 200 Longwood Avenue, Boston, MA 02115, USA
Biology Department, University of Pennsylvania, Philadelphia, PA 19104, USA
Dis Model Mech. 2016 Mar;9(3):229-31. doi: 10.1242/dmm.024810.
Drosophila melanogaster has been adopted as one of the most-used model systems since it was first introduced by Thomas Morgan for the study of heredity in the early 20th century. Its experimental tractability and similarity of its biological pathways to those of humans have placed the model at the forefront of research into human development and disease. With the ongoing accumulation of genetic tools and assays, the fly community has at its fingertips the resources to generate diverse Drosophila disease models for the study of genes and pathways involved in a wide range of disorders. In recent years, the fly has also been used successfully for drug screening. In this Editorial, we introduce a Special Collection of reviews, interviews and original research articles that highlight some of the many ways that Drosophila has made, and continues to make, an impact on basic biological insights and translational science.
自20世纪初托马斯·摩根首次引入黑腹果蝇用于遗传研究以来，它已成为最常用的模型系统之一。其实验易操作性以及生物途径与人类生物途径的相似性，使该模型处于人类发育和疾病研究的前沿。随着遗传工具和检测方法的不断积累，果蝇研究群体能够轻易获取资源，以生成各种用于研究广泛疾病中涉及的基因和途径的果蝇疾病模型。近年来，果蝇还成功用于药物筛选。在这篇社论中，我们介绍了一个特别专题，其中包括综述、访谈和原创研究文章，突出了果蝇在多个方面对基础生物学见解和转化科学产生影响以及持续发挥作用的多种方式。
