Department of Pathology/Comparative Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Department of Internal Medicine, Section on Gerontology and Geriatric Medicine, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Am J Primatol. 2021 Nov;83(11):e23260. doi: 10.1002/ajp.23260. Epub 2021 Apr 5.
Age-related neurodegeneration characteristic of late-onset Alzheimer's disease (LOAD) begins in middle age, well before symptoms. Translational models to identify modifiable risk factors are needed to understand etiology and identify therapeutic targets. Here, we outline the evidence supporting the vervet monkey (Chlorocebus aethiops sabaeus) as a model of aging-related AD-like neuropathology and associated phenotypes including cognitive function, physical function, glucose handling, intestinal physiology, and CSF, blood, and neuroimaging biomarkers. This review provides the most comprehensive multisystem description of aging in vervets to date. This review synthesizes a large body of evidence that suggests that aging vervets exhibit a coordinated suite of traits consistent with early AD and provide a powerful, naturally occurring model for LOAD. Notably, relationships are identified between AD-like neuropathology and modifiable risk factors. Gaps in knowledge and key limitations are provided to shape future studies to illuminate mechanisms underlying divergent neurocognitive aging trajectories and to develop interventions that increase resilience to aging-associated chronic disease, particularly, LOAD.
与年龄相关的神经退行性变是迟发性阿尔茨海默病（LOAD）的特征，它始于中年，远早于症状出现之前。为了了解病因和确定治疗靶点，需要有转化模型来确定可改变的风险因素。在这里，我们概述了支持用绿长尾猴（Chlorocebus aethiops sabaeus）作为与年龄相关的 AD 样神经病理学和相关表型（包括认知功能、身体功能、葡萄糖处理、肠道生理学以及 CSF、血液和神经影像学生物标志物）模型的证据。这篇综述提供了迄今为止关于绿长尾猴衰老的最全面的多系统描述。这篇综述综合了大量证据，表明衰老的绿长尾猴表现出与早期 AD 一致的协调特征，并为 LOAD 提供了一个强大的、自然发生的模型。值得注意的是，AD 样神经病理学与可改变的风险因素之间存在关联。本综述还提供了知识空白和关键限制，以指导未来的研究，阐明导致不同神经认知衰老轨迹的机制，并开发干预措施，以增加对与衰老相关的慢性疾病（尤其是 LOAD）的适应能力。
