Slat Emily, Freeman G Mark, Herzog Erik D
Department of Biology, Washington University, St. Louis, MO 63130, USA.
Handb Exp Pharmacol. 2013(217):105-23. doi: 10.1007/978-3-642-25950-0_5.
The master coordinator of daily schedules in mammals, located in the ventral hypothalamus, is the suprachiasmatic nucleus (SCN). This relatively small population of neurons and glia generates circadian rhythms in physiology and behavior and synchronizes them to local time. Recent advances have begun to define the roles of specific cells and signals (e.g., peptides, amino acids, and purine derivatives) within this network that generate and synchronize daily rhythms. Here we focus on the best-studied signals between neurons and between glia in the mammalian circadian system with an emphasis on time-of-day pharmacology. Where possible, we highlight how commonly used drugs affect the circadian system.
哺乳动物日常节律的主要协调者位于下丘脑腹侧，是视交叉上核（SCN）。这群相对较少的神经元和神经胶质细胞产生生理和行为的昼夜节律，并使其与当地时间同步。最近的进展已开始明确该网络中产生并同步日常节律的特定细胞和信号（如肽、氨基酸和嘌呤衍生物）的作用。在此，我们重点关注哺乳动物昼夜节律系统中神经元之间以及神经胶质细胞之间研究得最为充分的信号，尤其侧重于昼夜时间药理学。在可能的情况下，我们将强调常用药物如何影响昼夜节律系统。
