Department of Biology, University of Washington, Seattle, WA, USA; Graduate Program in Neuroscience, University of Washington, Seattle, WA, USA.
Graduate Program in Neuroscience, University of Washington, Seattle, WA, USA; Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA, USA; Department of Neurological Surgery, University of Washington, Seattle, WA, USA; Department of Pharmacology, University of Washington, Seattle, WA, USA.
Semin Cell Dev Biol. 2022 Jun;126:3-14. doi: 10.1016/j.semcdb.2021.05.034. Epub 2021 Jun 4.
Nearly all mammals display robust daily rhythms of physiology and behavior. These approximately 24-h cycles, known as circadian rhythms, are driven by a master clock in the suprachiasmatic nucleus (SCN) of the hypothalamus and affect biological processes ranging from metabolism to immune function. Perhaps the most overt output of the circadian clock is the sleep-wake cycle, the integrity of which is critical for health and homeostasis of the organism. In this review, we summarize our current understanding of the circadian regulation of sleep. We discuss the neural circuitry and molecular mechanisms underlying daily sleep timing, and the trajectory of circadian regulation of sleep across development. We conclude by proposing future research priorities for the field that will significantly advance our mechanistic understanding of the circadian regulation of sleep.
几乎所有哺乳动物都表现出强大的生理和行为日常节律。这些大约 24 小时的周期，称为昼夜节律，由下丘脑视交叉上核（SCN）中的主钟驱动，影响从新陈代谢到免疫功能等生物过程。昼夜钟最明显的输出也许是睡眠-觉醒周期，其完整性对生物体的健康和内稳态至关重要。在这篇综述中，我们总结了我们目前对睡眠的昼夜调节的理解。我们讨论了昼夜睡眠时间的神经回路和分子机制，以及睡眠的昼夜调节在整个发育过程中的轨迹。最后，我们提出了该领域未来的研究重点，这将极大地推进我们对睡眠的昼夜调节的机制理解。
