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小儿颈胸段巨大结核脓肿致脊髓压迫

A large tuberculosis abscess causing spinal cord compression of the cervico-thoracic region in a young child.

机构信息

Centre for Spine Studies and Surgery, Queens Medical Centre, West Block, D Floor, Derby Road, Nottingham NG7 2UH, UK.

出版信息

Eur Spine J. 2013 Jul;22(7):1459-63. doi: 10.1007/s00586-013-2729-1. Epub 2013 Apr 20.

Abstract

INTRODUCTION

Despite numerous descriptive publications, the guidelines for treatment of cervical spinal tuberculosis (TB) are not very clear. The authors report a case of a young girl with cervico-thoracic spinal TB extending from C5 to T3 vertebrae presenting with weakness of the right hand and unsteady gait.

CASE REPORT

An 11-year-old female who is an immigrant to the UK from Afghanistan, presented to our clinic with a 10-day history of difficulty in walking with an unsteady gait and 3-month history of progressive weakness in both her arms, the right side more affected than the left. Her immunisation history was unclear. Examination of the arms showed bilateral thenar and hypothenar wasting, more so on the right than the left. An MRI scan revealed a large para-spinal abscess extending from C3/4 to T4/5 with a significant anterior epidural cord compression from C5/6 to T2/3. Therapeutic/diagnostic aspiration was performed under ultrasound guidance and the aspirate was sent for microbiology. She was started empirically on multidrug anti-tubercular treatment and steroids. Although Ziehl-Neelsen stain was negative for acid-fast bacilli, microbiological confirmation of TB was obtained by positive TB culture sensitive to all first-line anti-TB drugs. She made a dramatic improvement within 3 weeks of anti-tubercular treatment. A follow-up MRI scan at 8 months showed complete resolution of the abscess. At 2 years of follow-up, she was a healthy looking child, back to her school with no residual clinical signs/symptoms of the disease.

CONCLUSION

Our case of cervico-thoracic tuberculous abscess in a young child suggests that even with incomplete neurological deficit caused by epidural cord compression, ultrasound (or CT)-guided aspiration and anti-tubercular medication provide acceptable results at 2 years of follow-up.

摘要

介绍

尽管有许多描述性出版物,但颈椎结核(TB)的治疗指南并不十分清楚。作者报告了一例年轻女孩患有颈胸段脊柱结核,病变从 C5 延伸至 T3 椎体,表现为右手无力和步态不稳。

病例报告

一位 11 岁的女孩,来自阿富汗的英国移民,因行走困难伴步态不稳就诊于我院,病史 10 天,且双臂进行性无力 3 个月,右侧较左侧更严重。她的免疫接种史不清楚。手臂检查显示双侧大鱼际和小鱼际萎缩,右侧比左侧更明显。MRI 扫描显示从 C3/4 到 T4/5 有一个大的椎旁脓肿,C5/6 到 T2/3 有明显的硬膜外脊髓前受压。在超声引导下进行了治疗/诊断性抽吸,抽吸物送检微生物学检查。她开始经验性接受多药抗结核治疗和类固醇治疗。虽然抗酸染色未发现抗酸杆菌,但通过对所有一线抗结核药物敏感的 TB 培养,获得了 TB 的微生物学确认。她在接受抗结核治疗 3 周内病情显著改善。8 个月时的随访 MRI 扫描显示脓肿完全消退。2 年随访时,她看起来健康,回到学校,没有疾病的残留临床体征/症状。

结论

我们报告的一例儿童颈胸段结核性脓肿病例表明,即使存在硬膜外脊髓压迫引起的不完全神经功能缺损,超声(或 CT)引导下抽吸和抗结核药物治疗在 2 年随访时也能获得可接受的结果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0b38/3698362/f6f781ee3aab/586_2013_2729_Figa_HTML.jpg

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