Nayak Hemanta K, Nishant Raizada, Sinha Nitin K, Daga Mradul Kumar
Department of Medicine, Maulana Azad Medical College, New Delhi, India.
BMJ Case Rep. 2013 Apr 18;2013:bcr2013009308. doi: 10.1136/bcr-2013-009308.
This case describes a 50-year-old man with multiple lytic bone lesions involving the skull, pelvis and ribs and associated features of anaemia, hypercalcaemia, azotaemia and subsequently found to be non-Hodgkin's lymphoma of anaplastic large T cell type (ALCL) on biopsy taken from a soft tissue mass in the anterior chest wall as an aetiology. We report this case with an aim to expand our knowledge of isolated osseous involvement in case of non-Hodgkin's lymphoma. This case was unique in the sense of an isolated osseous involvement in ALCL without any organomegaly and lymphadenopathy with a normal bone marrow biopsy finding. So in rare instances, T-cell lymphoma can present with a multiple lytic lesion, anaemia, hypercalcaemia. Although B-cell non-Hodgkin's lymphoma can present with the above manifestation, it is extremely rare for T-cell non-Hodgkin's lymphoma.
本病例描述了一名50岁男性,有累及颅骨、骨盆和肋骨的多发溶骨性骨病变,并伴有贫血、高钙血症、氮质血症等相关特征,随后经取自前胸壁软组织肿块的活检发现为间变性大T细胞型非霍奇金淋巴瘤(ALCL),以此作为病因。我们报告该病例旨在扩展我们对非霍奇金淋巴瘤孤立性骨受累情况的认识。该病例的独特之处在于ALCL出现孤立性骨受累,无任何器官肿大和淋巴结病,骨髓活检结果正常。所以在罕见情况下,T细胞淋巴瘤可表现为多发溶骨性病变、贫血、高钙血症。虽然B细胞非霍奇金淋巴瘤可出现上述表现,但T细胞非霍奇金淋巴瘤出现这种情况极为罕见。