Division of Surgical Oncology, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA.
Gastroenterol Res Pract. 2013;2013:207129. doi: 10.1155/2013/207129. Epub 2013 Mar 27.
Pancreatic adenocarcinoma is an aggressive disease that has poor outcomes despite maximal traditional therapies. Thus, treatment of this cancer demands innovative strategies to be used in addition to standing therapies in order to provide new avenues of care. Here, we describe the technique of using endoscopic ultrasound in order to directly inject both novel and conventional therapies into pancreatic tumors. We detail the rationale behind this strategy and the many benefits it provides. We then describe our technique in detail, including our experience injecting the AdV-tk adenoviral vector to create an in situ vaccine effect.
胰腺导管腺癌是一种侵袭性疾病，尽管采用了最大传统疗法，但其预后仍较差。因此，除了标准治疗之外，这种癌症的治疗还需要采用创新策略，以提供新的治疗途径。在这里，我们描述了使用内镜超声直接将新型和传统疗法注射到胰腺肿瘤中的技术。我们详细介绍了这种策略背后的原理及其提供的诸多好处。然后，我们详细描述了我们的技术，包括我们使用 AdV-tk 腺病毒载体进行注射以产生原位疫苗效应的经验。
