Viequeamide A 的全合成。

Total synthesis of the marine cyclic depsipeptide viequeamide a.

机构信息

School of Pharmaceutical Engineering, Shenyang Pharmaceutical University, Shenyang, People's Republic of China.

出版信息

J Nat Prod. 2013 May 24;76(5):974-8. doi: 10.1021/np4001027. Epub 2013 Apr 22.

Abstract

The first total synthesis of viequeamide A, a natural cyclic depsipeptide isolated from a marine button cyanobacterium, was achieved with the N-Me-Val-Thr peptide bond as the final macrocyclization site. The synthetic product gave nearly identical spectroscopic data to that reported for the natural product.

摘要

首次全合成了viequeamide A，这是一种从海洋纽扣蓝细菌中分离出的天然环二肽，采用 N-Me-Val-Thr 肽键作为最终大环化位点。合成产物的光谱数据与天然产物报道的几乎完全一致。