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从 sp.中分离得到的新型环二肽 PM170453 的分离和全合成

Isolation and Total Synthesis of PM170453, a New Cyclic Depsipeptide Isolated from sp.

机构信息

Research and Development, PharmaMar S.A., Avda. de los Reyes 1, Pol. In. La Mina, 28770 Madrid, Spain.

出版信息

Mar Drugs. 2024 Jun 28;22(7):303. doi: 10.3390/md22070303.

DOI:10.3390/md22070303
PMID:39057411
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11277655/
Abstract

In our continuing search for biologically active new chemical entities from marine organisms, we have isolated a new cyclic depsipeptide, PM170453 (), from a cyanobacterium of the genus sp., collected in the Indo-Pacific Ocean. Structure elucidation of the isolated compound was determined by spectroscopic methods including MS, H, C and 2D-NMR. To solve the supply problem for and progress pharmaceutical development, the total synthesis of that involves a total of 20 chemical steps in a convergent process was carried out. Its in vitro cytotoxic activity against four human tumor cell lines, as well as the inhibition of the interaction between the programmed cell death protein 1 PD-1 and its ligand PD-L1 were also evaluated.

摘要

在我们继续从海洋生物中寻找具有生物活性的新化学实体的过程中，我们从印度洋-太平洋采集的蓝细菌属中分离得到了一种新的环肽二肽 PM170453()。通过包括 MS、H、C 和 2D-NMR 在内的光谱方法确定了分离化合物的结构。为了解决 和推进药物开发的供应问题，我们进行了总共 20 步化学步骤的总合成，该合成采用收敛过程。还评估了它对四种人肿瘤细胞系的体外细胞毒性活性以及对程序性细胞死亡蛋白 1 (PD-1)与其配体 PD-L1 之间相互作用的抑制作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a1/11277655/24bcf65ad9b6/marinedrugs-22-00303-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a1/11277655/3bce29ab489f/marinedrugs-22-00303-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a1/11277655/de952205074a/marinedrugs-22-00303-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a1/11277655/e7bfec36af37/marinedrugs-22-00303-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a1/11277655/eb13d61a4c52/marinedrugs-22-00303-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a1/11277655/cca84b21176c/marinedrugs-22-00303-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a1/11277655/24bcf65ad9b6/marinedrugs-22-00303-g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a1/11277655/3bce29ab489f/marinedrugs-22-00303-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a1/11277655/de952205074a/marinedrugs-22-00303-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a1/11277655/e7bfec36af37/marinedrugs-22-00303-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a1/11277655/eb13d61a4c52/marinedrugs-22-00303-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a1/11277655/cca84b21176c/marinedrugs-22-00303-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/95a1/11277655/24bcf65ad9b6/marinedrugs-22-00303-g006.jpg

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