Williams Philip G, Yoshida Wesley Y, Quon Michael K, Moore Richard E, Paul Valerie J
Department of Chemistry, University of Hawaii at Manoa, Honolulu 96822, USA.
J Nat Prod. 2003 May;66(5):651-4. doi: 10.1021/np030050s.
Ulongapeptin (1), a cyclic depsipeptide, was isolated from a Palauan marine cyanobacterium Lyngbya sp. The gross structure was elucidated through one-dimensional TOCSY experiments and other spectroscopic techniques. The absolute and relative stereochemistry of the beta-amino acid, 3-amino-2-methyl-7-octynoic acid (AMO), in 1 was determined by synthesis of the saturated alpha-alkyl-beta-amino acid and Marfey's analysis of the acid hydrolysate of tetrahydro-1. Ulongapeptin (1) was cytotoxic against KB cells at an IC(50) value of 0.63 microM.
乌鲁那肽（1）是一种环缩肽，从帕劳海洋蓝藻Lyngbya sp.中分离得到。其总体结构通过一维全相关谱实验和其他光谱技术得以阐明。通过饱和α-烷基-β-氨基酸的合成以及对四氢-1的酸水解产物进行马尔菲分析，确定了1中β-氨基酸3-氨基-2-甲基-7-辛炔酸（AMO）的绝对和相对立体化学。乌鲁那肽（1）对KB细胞具有细胞毒性，IC50值为0.63微摩尔。
