Instituto de Biología Celular y Neurociencias, Facultad de Medicina, UBA, Paraguay 2155, 3° piso, 1121 ABG Buenos Aires, Argentina.
Neurobiol Learn Mem. 2013 Jul;103:19-25. doi: 10.1016/j.nlm.2013.04.006. Epub 2013 Apr 19.
The neocortex is thought to be a distributed learning system that gradually integrates semantic information into the initial mnemonic representation rapidly formed by the hippocampus after acquisition. Nevertheless, an emerging view suggests that some cortical regions, in particular the medial prefrontal cortex (mPFC), may also have a role during the initial steps of memory consolidation as well as in the recall of recent memories. Here, we show that mPFC plays a critical role during the first few hours of inhibitory avoidance memory consolidation and is necessary for the normal retrieval of both recent and remote memories, supporting the idea that involvement of neocortical areas in memory processing is not restricted to the late post-training consolidation phase.
新皮层被认为是一个分布式学习系统，它逐渐将语义信息整合到海马体在获取后快速形成的初始记忆表象中。然而，一种新的观点表明，一些皮层区域，特别是内侧前额叶皮层（mPFC），在记忆巩固的初始阶段以及最近记忆的回忆中也可能发挥作用。在这里，我们表明 mPFC 在抑制回避记忆巩固的头几个小时中起着关键作用，并且对于最近和遥远记忆的正常检索都是必需的，这支持了这样一种观点，即新皮层区域参与记忆处理不仅限于训练后的后期巩固阶段。
