Kumar Prabhat, Ghosh Soumik, Rath Deepak, Gadpayle A K
Department of Medicine, PGIMER & Dr Ram Manohar Lohia Hospital, New Delhi, India.
BMJ Case Rep. 2013 Apr 22;2013:bcr2013008714. doi: 10.1136/bcr-2013-008714.
Liver abscesses are infectious, space occupying lesions in the liver, the two most common abscesses being pyogenic and amoebic. A pyogenic liver abscess (PLA) is a rare condition with a reported incidence of 20 per 100 000 hospital admissions in the western population. The right lobe of the liver is the most common site in both types of liver abscess. Clinical presentation is elusive with complaints of fever, right upper quadrant pain in the abdomen and hepatomegaly with or without jaundice. The aetiology of PLA has changed in the past few decades and may be of biliary, portal, arterial or traumatic origin, but many cases are still cryptogenic. The most common organisms causing PLA are Gram-negative aerobes, especially Escherichia coli and Klebsiella pneumoniae. Studies have shown a high degree of antimicrobial susceptibility of isolated organism resulting in an overall lower mortality in PLA. Here, we present a case of PLA caused by multidrug-resistant Citrobacter freundii, which is an unusual organism to be isolated.
肝脓肿是肝脏内的感染性占位性病变,最常见的两种脓肿是化脓性和阿米巴性。化脓性肝脓肿(PLA)是一种罕见疾病,在西方人群中,每10万例住院患者中的发病率为20例。在两种类型的肝脓肿中,肝右叶都是最常见的部位。临床表现不明确,患者会出现发热、右上腹腹痛以及肝脏肿大,可伴有或不伴有黄疸。在过去几十年中,PLA的病因发生了变化,其病因可能是胆汁性、门静脉性、动脉性或创伤性,但许多病例仍病因不明。引起PLA最常见的微生物是革兰氏阴性需氧菌,尤其是大肠杆菌和肺炎克雷伯菌。研究表明,分离出的微生物对抗菌药物具有高度敏感性,导致PLA的总体死亡率较低。在此,我们报告一例由多重耐药弗氏柠檬酸杆菌引起的PLA病例,该菌是一种不常见的分离菌。