Müller G, Klingberg F
Paul Flechsig Institute for Brain Research, Department of Neurophysiology, Karl Marx University, Leipzig, GDR.
Biomed Biochim Acta. 1990;49(1):51-8.
Adult male hooded rats of the Long-Evans strain were investigated before and after lesions of the ventral nucleus reticularis pontis oralis (vRPO) in an open field test (OF) and in a Y-maze. The OF and the neurological findings were scarcely changed. Startle responses were strongly reduced and also horizontal head and body turning in the OF were significantly reduced. The retention of Y-maze avoidance tasks was reduced and relearning of the tasks relatively slow. Brightness discrimination remained unaffected by the lesion. The postoperative active avoidance learning of a new task in the jump test box was impossible. Postoperative learning of a thirst-motivated labyrinth task was significantly retarded compared with unoperated control rats. The vRPO lesion syndrome is quite different compared with 1 mm more dorsal (dRPO) and 1 mm more posterior (vRPC, dRPC) placed lesions and underlines the hypothesis of the functional heterogeneity of the pontine reticular formation.
在旷场试验（OF）和Y迷宫中，对成年雄性长-伊文斯品系的有帽大鼠在脑桥嘴侧网状核腹侧部（vRPO）损伤前后进行了研究。旷场试验和神经学检查结果几乎没有变化。惊吓反应大幅降低，在旷场试验中头部和身体的水平转动也显著减少。Y迷宫回避任务的记忆保持能力下降，且任务重新学习相对缓慢。亮度辨别不受损伤影响。术后在跳跃试验箱中无法进行新任务的主动回避学习。与未手术的对照大鼠相比，术后口渴驱动的迷宫任务学习明显延迟。与损伤部位在背侧多1毫米（dRPO）和后侧多1毫米（vRPC、dRPC）的情况相比，vRPO损伤综合征有很大不同，这也强化了脑桥网状结构功能异质性的假说。
