Division of Nutrition & Health, School & Graduate School of Life Studies, Sugiyama Jogakuen University, Nagoya 464-8662, Japan.
J Atheroscler Thromb. 2013;20(6):591-600. doi: 10.5551/jat.17301. Epub 2013 Apr 19.
To investigate the acute effects of the simultaneous ingestion of fructose and fat on postprandial lipoprotein metabolism in healthy young women.
Nine young healthy Japanese women with a normal weight (body mass index: 18.5≤-< 25 kg/m(2)), a normal ovarian cycle and an apolipoprotein E 3/3 phenotype were enrolled as participants and studied on four occasions. At each session, the subjects ingested one of four beverages containing either glucose or fructose (0.5 g/kg body weight each) with or without OFTT cream (1 g/kg, 0.35 g/ kg as fat) in a randomized crossover design. Blood samples were collected at baseline and at 0.5, 1, 2, 4 and 6 hours after ingestion.
The ingestion of fructose combined with fat led to significantly higher rises in the serum triglyceride (TG), remnant-like particle (RLP)-TG, remnant lipoprotein-cholesterol (RemL-C) and apolipoprotein B-48 (apoB48) concentrations with delayed peaks compared with that observed following ingestion of the other three types of beverages. The incremental area under the curve (ΔAUC)-TG and ΔAUC-apoB48 were larger than those observed for the ingestion of fat only. The serum RLP-TG and apoB48 concentrations returned to the fasting levels (0 hours) at the end of the test (6 hours) following the ingestion of fat only; however, these concentrations did not return to the fasting levels following the intake of fructose combined with fat.
These findings suggest a delay in the clearance of intestinal TG-rich lipoproteins, namely chylomicron and its remnant, following the ingestion of fructose combined with fat. The simultaneous ingestion of fructose and fat markedly enhances postprandial exogenous lipidemia in young healthy Japanese women.
研究健康年轻女性同时摄入果糖和脂肪对餐后脂蛋白代谢的急性影响。
共纳入 9 名体重正常（体重指数：18.5≤-<25kg/m(2)）、卵巢周期正常、载脂蛋白 E 3/3 表型的年轻健康日本女性作为研究对象，在 4 个时间点进行研究。在每个时间点，受试者随机交叉摄入 4 种饮料中的一种，分别含有葡萄糖或果糖（0.5g/kg 体重），或含或不含 OFTT 霜（1g/kg，0.35g/kg 为脂肪）。在摄入前和摄入后 0.5、1、2、4 和 6 小时采集血样。
与摄入其他 3 种饮料相比，果糖与脂肪同时摄入导致血清甘油三酯（TG）、残粒样颗粒（RLP）-TG、残粒脂蛋白胆固醇（RemL-C）和载脂蛋白 B-48（apoB48）浓度升高更明显，峰值延迟。与仅摄入脂肪相比，TG 和 apoB48 的曲线下面积增量（ΔAUC-TG 和 ΔAUC-apoB48）更大。仅摄入脂肪后，血清 RLP-TG 和 apoB48 浓度在试验结束时（6 小时）恢复到空腹水平（0 小时）；然而，在摄入果糖和脂肪后，这些浓度并未恢复到空腹水平。
这些发现表明，在摄入果糖和脂肪后，肠道富含 TG 的脂蛋白，即乳糜微粒及其残粒，的清除延迟。在健康年轻日本女性中，果糖和脂肪同时摄入可显著增强餐后外源性血脂血症。
