Division of Nutrition and Health, School & Graduate School of Life Studies, Sugiyama Jogakuen University, Nagoya, Japan.
J Atheroscler Thromb. 2011;18(10):891-900. doi: 10.5551/jat.8482. Epub 2011 Jun 17.
To compare the acute effects of shortly pre- vs. postprandial exercise on postprandial lipid metabolism in healthy but sedentary young Japanese women.
Healthy young Japanese women with a sedentary lifestyle, normal weight (18.5 ≤ BMI < 25), normal ovarian cycle, and apolipoprotein E3/3 were selected as participants. A single bout of walking exercise was performed 20 min after (Exp. 1) or 50 min before (Exp. 2) the intake of oral fat tolerance test (OFTT) cream (1 g/kg body weight) at about 50% Vo(2)max for 30 min on a motorized treadmill. A control trial without exercise was also performed in each experiment. Each subject performed 2 trials in a randomized, cross-over design. Venous blood samples were drawn before the preprandial exercise (-1 h, Exp. 2 only) [corrected] and before (0 h) and 1, 2, 4 and 6 h after the fat intake for the determination of triglyceride (TG), apolipoprotein B-48 (apoB48), remnant-like particle-TG (RLP-TG), lactate, free fatty acid (FFA), insulin, and glucose.
In both experiments, postprandial serum TG concentrations in the exercise group were lower, but not significantly, than those in the control. In Exp. 1, incremental areas under the curve (IAUC) for TG and RLP-TG were slightly, but not significantly, smaller in the postprandial exercise group than the control. The values of apoB48, a marker of the chylomicron particle number, at 2, 4, and 6 h after the fat intake and IAUC for apoB48 were significantly lower in the postprandial exercise group than the control. In Exp. 2, IAUC for TG, RLP-TG, and apoB48 were not significantly different between the two groups.
The present findings suggest that postprandial, but not preprandial, exercise may reduce the number of chylomicrons and chylomicron remnants and improve exogenous lipoprotein metabolism. Postprandial exercise is more effective for improving postprandial lipoprotein metabolism than preprandial exercise.
比较健康但久坐的年轻日本女性预餐后和餐后即刻运动对餐后脂质代谢的急性影响。
选择生活方式久坐、体重正常（18.5≤BMI<25）、正常卵巢周期和载脂蛋白 E3/3 的年轻日本健康女性作为参与者。在大约 50%Vo(2)max 下，在电动跑步机上以 1 g/kg 体重的口服脂肪耐量试验（OFTT）霜后 20 分钟（实验 1）或 50 分钟（实验 2）进行单次 30 分钟的步行运动。在每个实验中还进行了无运动的对照试验。每个受试者在随机交叉设计中进行了 2 次试验。在预餐前运动前（实验 2 仅为-1 h）[校正]和脂肪摄入前（0 h）以及 1、2、4 和 6 h 抽取静脉血样，用于测定甘油三酯（TG）、载脂蛋白 B-48（apoB48）、残粒样颗粒-TG（RLP-TG）、乳酸、游离脂肪酸（FFA）、胰岛素和葡萄糖。
在两项实验中，运动组的餐后血清 TG 浓度较低，但无统计学意义。在实验 1 中，餐后运动组的 TG 和 RLP-TG 的增量曲线下面积（IAUC）略低于对照组，但无统计学意义。脂肪摄入后 2、4 和 6 h 的 apoB48 值和 apoB48 的 IAUC 以及作为乳糜微粒颗粒数标志物的 apoB48 值在运动组均明显低于对照组。在实验 2 中，两组之间的 TG、RLP-TG 和 apoB48 的 IAUC 无显著差异。
本研究结果表明，餐后而非预餐运动可能会减少乳糜微粒和乳糜微粒残粒的数量，并改善外源性脂蛋白代谢。与预餐运动相比，餐后运动对改善餐后脂蛋白代谢更有效。
