• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Sporadic and reversible chromothripsis in chronic lymphocytic leukemia revealed by longitudinal genomic analysis.

作者信息

Bassaganyas L, Beà S, Escaramís G, Tornador C, Salaverria I, Zapata L, Drechsel O, Ferreira P G, Rodriguez-Santiago B, Tubio J M C, Navarro A, Martín-García D, López C, Martínez-Trillos A, López-Guillermo A, Gut M, Ossowski S, López-Otín C, Campo E, Estivill X

机构信息

1] Center for Genomic Regulation (CRG), Barcelona, Spain [2] Pompeu Fabra University (UPF) Barcelona, Spain [3] Centro de Investigación Biomédica en Red en Epidemiología y Salud Pública (CIBERESP), Barcelona, Spain [4] Hospital del Mar Medical Research Institute (IMIM), Barcelona, Spain.

出版信息

Leukemia. 2013 Dec;27(12):2376-9. doi: 10.1038/leu.2013.127. Epub 2013 Apr 24.

DOI:10.1038/leu.2013.127
PMID:23612016
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3865532/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23a5/3865532/1dd407747a3e/leu2013127f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23a5/3865532/1dd407747a3e/leu2013127f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/23a5/3865532/1dd407747a3e/leu2013127f1.jpg

相似文献

1
Sporadic and reversible chromothripsis in chronic lymphocytic leukemia revealed by longitudinal genomic analysis.通过纵向基因组分析揭示的慢性淋巴细胞白血病中的散发性和可逆性染色体碎裂
Leukemia. 2013 Dec;27(12):2376-9. doi: 10.1038/leu.2013.127. Epub 2013 Apr 24.
2
Large but not small copy-number alterations correlate to high-risk genomic aberrations and survival in chronic lymphocytic leukemia: a high-resolution genomic screening of newly diagnosed patients.大的而非小的拷贝数改变与慢性淋巴细胞白血病的高风险基因组畸变及生存相关：对新诊断患者的高分辨率基因组筛查
Leukemia. 2010 Jan;24(1):211-5. doi: 10.1038/leu.2009.187. Epub 2009 Sep 10.
3
Array-based genomic screening at diagnosis and during follow-up in chronic lymphocytic leukemia.基于阵列的基因组筛查在慢性淋巴细胞白血病诊断时和随访期间的应用。
Haematologica. 2011 Aug;96(8):1161-9. doi: 10.3324/haematol.2010.039768. Epub 2011 May 5.
4
Comparative genomic hybridization and fluorescence in situ hybridization in chronic lymphocytic leukemia.慢性淋巴细胞白血病中的比较基因组杂交和荧光原位杂交
Methods Mol Med. 2004;97:145-57. doi: 10.1385/1-59259-760-2:145.
5
Aberrations of chromosome 6 in 193 newly diagnosed untreated cases of chronic lymphocytic leukemia.193例新诊断未治疗的慢性淋巴细胞白血病患者的6号染色体畸变
Cancer Genet Cytogenet. 1991 May;53(1):35-43. doi: 10.1016/0165-4608(91)90112-8.
6
Case of chronic lymphocytic leukemia with unusual chromosome aberrations.
Int J Hematol. 2004 Nov;80(4):351-3. doi: 10.1532/ijh97.a10323.
7
Paraoxonase 1 (PON1) Q192R and L55M Polymorphisms as Potential Predisposition Factors for Chronic Lymphocytic Leukemia.对氧磷酶1（PON1）Q192R和L55M多态性作为慢性淋巴细胞白血病的潜在易感因素
Anticancer Res. 2019 Jun;39(6):2861-2869. doi: 10.21873/anticanres.13415.
8
Chromosomal aberrations in progressive and indolent chronic B-lymphocytic leukaemia. A longitudinal study.进展性和惰性慢性B淋巴细胞白血病中的染色体畸变。一项纵向研究。
Acta Oncol. 1988;27(5):473-7. doi: 10.3109/02841868809093573.
9
High-density screening reveals a different spectrum of genomic aberrations in chronic lymphocytic leukemia patients with 'stereotyped' IGHV3-21 and IGHV4-34 B-cell receptors.高密度筛选揭示了具有“定型”IGHV3-21 和 IGHV4-34 B 细胞受体的慢性淋巴细胞白血病患者中不同的基因组异常谱。
Haematologica. 2010 Sep;95(9):1519-25. doi: 10.3324/haematol.2009.021014. Epub 2010 Apr 26.
10
Clonal evolution, genomic drivers, and effects of therapy in chronic lymphocytic leukemia.慢性淋巴细胞白血病中的克隆进化、基因组驱动因素和治疗效果。
Clin Cancer Res. 2013 Jun 1;19(11):2893-904. doi: 10.1158/1078-0432.CCR-13-0138. Epub 2013 Apr 25.

引用本文的文献

1
Chromoanagenesis Detection in Chronic Lymphocytic Leukemia.慢性淋巴细胞白血病中的染色体混乱检测
Methods Mol Biol. 2025;2968:231-248. doi: 10.1007/978-1-0716-4750-9_13.
2
Chromothripsis.染色体碎裂
Methods Mol Biol. 2025;2968:3-33. doi: 10.1007/978-1-0716-4750-9_1.
3
Abnormalities Are Underlying the Poor Outcome Associated with Chromothripsis in Chronic Lymphocytic Leukemia Patients with Complex Karyotype.异常是复杂核型慢性淋巴细胞白血病患者中与染色体碎裂相关的不良预后的潜在原因。

本文引用的文献

1
The evolutionary biography of chronic lymphocytic leukemia.慢性淋巴细胞白血病的进化生物学
Nat Genet. 2013 Mar;45(3):229-31. doi: 10.1038/ng.2556. Epub 2013 Feb 24.
2
Evolution and impact of subclonal mutations in chronic lymphocytic leukemia.慢性淋巴细胞白血病亚克隆突变的演变和影响。
Cell. 2013 Feb 14;152(4):714-26. doi: 10.1016/j.cell.2013.01.019.
3
High-resolution genomic profiling of chronic lymphocytic leukemia reveals new recurrent genomic alterations.慢性淋巴细胞白血病的高分辨率基因组分析揭示了新的复发性基因组改变。
Cancers (Basel). 2022 Jul 29;14(15):3715. doi: 10.3390/cancers14153715.
4
Insight into the Molecular Basis Underlying Chromothripsis.解析染色体碎裂的分子基础。
Int J Mol Sci. 2022 Mar 19;23(6):3318. doi: 10.3390/ijms23063318.
5
Chromothripsis in Chronic Lymphocytic Leukemia: A Driving Force of Genome Instability.慢性淋巴细胞白血病中的染色体碎裂：基因组不稳定的驱动因素
Front Oncol. 2021 Nov 26;11:771664. doi: 10.3389/fonc.2021.771664. eCollection 2021.
6
Postmortem Examination of an Aggressive Case of Medullary Thyroid Carcinoma Characterized by Catastrophic Genomic Abnormalities.一例具有灾难性基因组异常的侵袭性甲状腺髓样癌尸检报告
JCO Precis Oncol. 2017 Jun 5;1. doi: 10.1200/PO.16.00063. eCollection 2017.
7
The landscape of chromothripsis across adult cancer types.成人癌症类型中染色体重排的全景。
Nat Commun. 2020 May 8;11(1):2320. doi: 10.1038/s41467-020-16134-7.
8
Chromoanagenesis: cataclysms behind complex chromosomal rearrangements.染色体骤变：复杂染色体重排背后的灾难
Mol Cytogenet. 2019 Feb 11;12:6. doi: 10.1186/s13039-019-0415-7. eCollection 2019.
9
aberrations in chronic lymphocytic leukemia: an overview of the clinical implications of improved diagnostics.慢性淋巴细胞白血病的畸变：诊断改进的临床意义概述。
Haematologica. 2018 Dec;103(12):1956-1968. doi: 10.3324/haematol.2018.187583. Epub 2018 Nov 15.
10
Chromothripsis in acute myeloid leukemia: biological features and impact on survival.急性髓系白血病中的染色体重排：生物学特征及其对生存的影响。
Leukemia. 2018 Jul;32(7):1609-1620. doi: 10.1038/s41375-018-0035-y. Epub 2018 Feb 23.
Blood. 2012 Dec 6;120(24):4783-94. doi: 10.1182/blood-2012-04-423517. Epub 2012 Oct 9.
4
Chromothripsis and cancer: causes and consequences of chromosome shattering.染色体重排与癌症：染色体破碎的原因与后果。
Nat Rev Cancer. 2012 Oct;12(10):663-70. doi: 10.1038/nrc3352. Epub 2012 Sep 13.
5
Genome sequencing of pediatric medulloblastoma links catastrophic DNA rearrangements with TP53 mutations.对小儿髓母细胞瘤的基因组测序将灾难性的 DNA 重排与 TP53 突变联系起来。
Cell. 2012 Jan 20;148(1-2):59-71. doi: 10.1016/j.cell.2011.12.013.
6
Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia.外显子组测序鉴定出慢性淋巴细胞白血病中剪接因子 SF3B1 基因的反复突变。
Nat Genet. 2011 Dec 11;44(1):47-52. doi: 10.1038/ng.1032.
7
Chromothripsis is a common mechanism driving genomic rearrangements in primary and metastatic colorectal cancer.染色体重排是导致原发性和转移性结直肠癌基因组重排的常见机制。
Genome Biol. 2011 Oct 19;12(10):R103. doi: 10.1186/gb-2011-12-10-r103.
8
ATM gene alterations in chronic lymphocytic leukemia patients induce a distinct gene expression profile and predict disease progression.ATM 基因突变在慢性淋巴细胞白血病患者中诱导独特的基因表达谱，并可预测疾病进展。
Haematologica. 2012 Jan;97(1):47-55. doi: 10.3324/haematol.2011.049270. Epub 2011 Oct 11.
9
Inhibitor of kappa B epsilon (IκBε) is a non-redundant regulator of c-Rel-dependent gene expression in murine T and B cells.κB 抑制蛋白ε（IκBε）是调控鼠 T 和 B 细胞中 c-Rel 依赖基因表达的非冗余调节剂。
PLoS One. 2011;6(9):e24504. doi: 10.1371/journal.pone.0024504. Epub 2011 Sep 6.
10
Chromothripsis identifies a rare and aggressive entity among newly diagnosed multiple myeloma patients.染色体重排鉴定出多发性骨髓瘤初诊患者中一种罕见且侵袭性的实体。
Blood. 2011 Jul 21;118(3):675-8. doi: 10.1182/blood-2011-03-344069. Epub 2011 May 31.