Section of Inorganic and Analytical Chemistry, Department of Chemistry, University of Ioannina, 45110 Ioannina, Greece.
Metallomics. 2013 Jun;5(6):569-96. doi: 10.1039/c3mt00046j.
Silver is proving to have a number of medicinal applications; as an antiseptic, an antibacterial, and an anti-inflammatory, while any biological role for it is currently unknown. Silver compounds and their therapeutic potentials are under consideration from many research groups, while a number of early reviews recording the advances of silver(I) chemistry are also available. However there is no recent report on the screening for the antitumor potential of silver(I) compounds. This review focuses upon results obtained on the anti-proliferative activity of silver compounds in the past years. This survey shows that silver(I) complexes containing various type of ligands such as carboxylic acids, amino acids, nitrogen, phosphorus or sulfur donor ligands, exhibit selectivity against a variety of cancer cells. The role of the coordination number, which is related to either the stability or hydrophilicity-lipophilicity of a complex, is not clearly elucidated within this review.
银被证明具有许多药用特性；作为一种防腐剂、抗菌剂和抗炎剂，尽管目前还不清楚它的任何生物学作用。许多研究小组正在研究银化合物及其治疗潜力，同时也有许多早期的综述记录了银（I）化学的进展。然而，目前没有关于银（I）化合物抗肿瘤潜力筛选的最新报道。本综述重点介绍了过去几年中关于银化合物抗增殖活性的研究结果。这项调查表明，含有各种配体的银（I）配合物，如羧酸、氨基酸、氮、磷或硫供体配体，对多种癌细胞具有选择性。在本综述中，配位数的作用（与配合物的稳定性或亲水性-疏水性有关）没有得到明确阐明。
