葡萄糖对胰高血糖素分泌的调控：其涉及的远不止钾离子ATP通道。 - Suppr

Suppr

超能文献

Glucose control of glucagon secretion: there is more to it than KATP channels.

作者信息

Gylfe Erik

机构信息

Department of Medical Cell Biology, Uppsala University, Uppsala, Sweden.

出版信息

Diabetes. 2013 May;62(5):1391-3. doi: 10.2337/db13-0193.

DOI:10.2337/db13-0193

PMID:23613562

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3636606/

Abstract

摘要

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e0f3/3636606/a6466a9877ba/1391fig1.jpg

相似文献

Glucose control of glucagon secretion: there is more to it than KATP channels.葡萄糖对胰高血糖素分泌的调控：其涉及的远不止钾离子ATP通道。

Diabetes. 2013 May;62(5):1391-3. doi: 10.2337/db13-0193.

Tolbutamide controls glucagon release from mouse islets differently than glucose: involvement of K(ATP) channels from both α-cells and δ-cells.甲苯磺丁脲对小鼠胰岛释放胰高血糖素的作用不同于葡萄糖：涉及到 α 细胞和 δ 细胞的 K(ATP)通道。

Diabetes. 2013 May;62(5):1612-22. doi: 10.2337/db12-0347. Epub 2013 Feb 4.

Glucagonotropic and Glucagonostatic Effects of KATP Channel Closure and Potassium Depolarization.ATP敏感性钾通道关闭和钾离子去极化对胰高血糖素分泌的促进及抑制作用

Endocrinology. 2021 Jan 1;162(1). doi: 10.1210/endocr/bqaa136.

Small Mouse Islets Are Deficient in Glucagon-Producing Alpha Cells but Rich in Somatostatin-Secreting Delta Cells.小型小鼠胰岛中产生胰高血糖素的α细胞不足，但分泌生长抑素的δ细胞丰富。

J Diabetes Res. 2016;2016:4930741. doi: 10.1155/2016/4930741. Epub 2016 Jul 18.

K channel blockers control glucagon secretion by distinct mechanisms: A direct stimulation of α-cells involving a [Ca] rise and an indirect inhibition mediated by somatostatin.K 通道阻滞剂通过不同的机制控制胰高血糖素的分泌：一种是通过 [Ca] 上升直接刺激α细胞，另一种是通过生长抑素介导的间接抑制。

Mol Metab. 2021 Nov;53:101268. doi: 10.1016/j.molmet.2021.101268. Epub 2021 Jun 9.

Tambulin from Zanthoxylum armatum acutely potentiates the glucose-induced insulin secretion via K-independent Ca-dependent amplifying pathway.花椒中的荜茇碱通过非 K 依赖、Ca 依赖的扩增途径，显著增强葡萄糖诱导的胰岛素分泌。

Biomed Pharmacother. 2019 Dec;120:109348. doi: 10.1016/j.biopha.2019.109348. Epub 2019 Oct 17.

Role of KATP channels in glucose-regulated glucagon secretion and impaired counterregulation in type 2 diabetes.KATP 通道在葡萄糖调节的胰高血糖素分泌中的作用及其在 2 型糖尿病中受损的对抗调节作用。

Cell Metab. 2013 Dec 3;18(6):871-82. doi: 10.1016/j.cmet.2013.10.014.

Pharmacological approach to understanding the control of insulin secretion in human islets.探讨人类胰岛胰岛素分泌调控的药理学方法。

Diabetes Obes Metab. 2017 Aug;19(8):1061-1070. doi: 10.1111/dom.12887. Epub 2017 Mar 31.

Somatostatin promotes glucose generation of Caoscillations in pancreatic islets both in the absence and presence of tolbutamide.生长抑素促进胰岛中葡萄糖诱导的钙振荡，无论是否存在甲苯磺丁脲。

Cell Calcium. 2018 Sep;74:35-42. doi: 10.1016/j.ceca.2018.05.007. Epub 2018 Jun 1.

Automated recognition and quantification of pancreatic islets in Zucker diabetic fatty rats treated with exendin-4.自动化识别和定量分析接受 exendin-4 治疗的 Zucker 糖尿病肥胖大鼠的胰岛。

J Endocrinol. 2013 Jan 2;216(1):13-20. doi: 10.1530/JOE-12-0456. Print 2013 Jan.

引用本文的文献

The Regulation of Metabolic Homeostasis by Incretins and the Metabolic Hormones Produced by Pancreatic Islets.肠促胰岛素和胰岛产生的代谢激素对代谢稳态的调节

Diabetes Metab Syndr Obes. 2024 Jun 13;17:2419-2456. doi: 10.2147/DMSO.S415934. eCollection 2024.

Glucose Controls Glucagon Secretion by Regulating Fatty Acid Oxidation in Pancreatic α-Cells.葡萄糖通过调节胰腺α细胞中的脂肪酸氧化来控制胰高血糖素的分泌。

Diabetes. 2023 Oct 1;72(10):1446-1459. doi: 10.2337/db23-0056.

Arginine-vasopressin mediates counter-regulatory glucagon release and is diminished in type 1 diabetes.精氨酸加压素介导的代偿性胰高血糖素释放，并在 1 型糖尿病中减少。

Elife. 2021 Nov 17;10:e72919. doi: 10.7554/eLife.72919.

Glucokinase intrinsically regulates glucose sensing and glucagon secretion in pancreatic alpha cells.葡萄糖激酶内在调节胰腺α细胞的葡萄糖感应和胰高血糖素分泌。

Sci Rep. 2020 Nov 19;10(1):20145. doi: 10.1038/s41598-020-76863-z.

Metabolism and growth adaptation to environmental conditions in Drosophila.果蝇对环境条件的代谢和生长适应。

Cell Mol Life Sci. 2020 Nov;77(22):4523-4551. doi: 10.1007/s00018-020-03547-2. Epub 2020 May 24.

Reduced somatostatin signalling leads to hypersecretion of glucagon in mice fed a high-fat diet.高脂饮食喂养导致小鼠生长抑素信号转导减少，胰高血糖素分泌过多。

Mol Metab. 2020 Oct;40:101021. doi: 10.1016/j.molmet.2020.101021. Epub 2020 May 21.

Modelling of dysregulated glucagon secretion in type 2 diabetes by considering mitochondrial alterations in pancreatic α-cells.通过考虑胰腺α细胞中的线粒体改变对2型糖尿病中胰高血糖素分泌失调进行建模。

R Soc Open Sci. 2020 Jan 22;7(1):191171. doi: 10.1098/rsos.191171. eCollection 2020 Jan.

Patterns of postmeal insulin secretion in individuals with sulfonylurea-treated neonatal diabetes show predominance of non-K-channel pathways.磺酰脲类药物治疗的新生儿糖尿病个体餐后胰岛素分泌模式显示非 K 通道途径占主导地位。

BMJ Open Diabetes Res Care. 2019 Dec 18;7(1):e000721. doi: 10.1136/bmjdrc-2019-000721. eCollection 2019.

CPT1a-Dependent Long-Chain Fatty Acid Oxidation Contributes to Maintaining Glucagon Secretion from Pancreatic Islets.CPT1a 依赖性长链脂肪酸氧化有助于维持胰岛的胰高血糖素分泌。

Cell Rep. 2018 Jun 12;23(11):3300-3311. doi: 10.1016/j.celrep.2018.05.035.

Altered pancreatic islet morphology and function in SGLT1 knockout mice on a glucose-deficient, fat-enriched diet.在葡萄糖缺乏、脂肪丰富的饮食中，SGLT1 基因敲除小鼠的胰腺胰岛形态和功能发生改变。

Mol Metab. 2018 Jul;13:67-76. doi: 10.1016/j.molmet.2018.05.011. Epub 2018 May 23.

本文引用的文献

Diabetes. 2013 May;62(5):1612-22. doi: 10.2337/db12-0347. Epub 2013 Feb 4.

Isolated mouse islets respond to glucose with an initial peak of glucagon release followed by pulses of insulin and somatostatin in antisynchrony with glucagon.分离的胰岛小鼠对葡萄糖的反应表现为初始的胰高血糖素释放峰，随后伴随着胰岛素和生长抑素的脉冲释放，与胰高血糖素呈反相。

Biochem Biophys Res Commun. 2012 Jan 27;417(4):1219-23. doi: 10.1016/j.bbrc.2011.12.113. Epub 2011 Dec 29.

Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover.胰高血糖素中心性糖尿病重构：病理生理和治疗重塑。

J Clin Invest. 2012 Jan;122(1):4-12. doi: 10.1172/JCI60016. Epub 2012 Jan 3.

Brain glucose sensing and neural regulation of insulin and glucagon secretion.脑葡萄糖感应与胰岛素和胰高血糖素分泌的神经调节。

Diabetes Obes Metab. 2011 Oct;13 Suppl 1:82-8. doi: 10.1111/j.1463-1326.2011.01453.x.

AMP-activated protein kinase regulates glucagon secretion from mouse pancreatic alpha cells.AMP 激活的蛋白激酶调节小鼠胰腺α细胞的胰高血糖素分泌。

Diabetologia. 2011 Jan;54(1):125-34. doi: 10.1007/s00125-010-1929-z. Epub 2010 Oct 13.

Glucose suppression of glucagon secretion: metabolic and calcium responses from alpha-cells in intact mouse pancreatic islets.葡萄糖抑制胰高血糖素分泌：完整胰岛中胰岛 α 细胞的代谢和钙反应。

J Biol Chem. 2010 May 7;285(19):14389-98. doi: 10.1074/jbc.M109.069195. Epub 2010 Mar 15.

Glucose generates coincident insulin and somatostatin pulses and antisynchronous glucagon pulses from human pancreatic islets.葡萄糖可从人胰岛中产生同步的胰岛素和生长抑素脉冲，以及非同步的胰高血糖素脉冲。

Endocrinology. 2009 Dec;150(12):5334-40. doi: 10.1210/en.2009-0600. Epub 2009 Oct 9.

K(ATP)-channels and glucose-regulated glucagon secretion.钾离子通道与葡萄糖调节的胰高血糖素分泌

Trends Endocrinol Metab. 2008 Oct;19(8):277-84. doi: 10.1016/j.tem.2008.07.003. Epub 2008 Sep 2.

Glucose inhibits glucagon secretion by a direct effect on mouse pancreatic alpha cells.葡萄糖通过直接作用于小鼠胰腺α细胞来抑制胰高血糖素分泌。

Diabetologia. 2007 Feb;50(2):370-9. doi: 10.1007/s00125-006-0511-1. Epub 2006 Nov 29.

Paradoxical stimulation of glucagon secretion by high glucose concentrations.高血糖浓度对胰高血糖素分泌的反常刺激。

Diabetes. 2006 Aug;55(8):2318-23. doi: 10.2337/db06-0080.

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验