Bae Jae-Bum
Division of Structural and Functional Genomics, Center for Genome Sciences, Korea National Institute of Health, Cheongwon 363-951, Korea.
Genomics Inform. 2013 Mar;11(1):7-14. doi: 10.5808/GI.2013.11.1.7. Epub 2013 Mar 31.
As the International Human Epigenome Consortium (IHEC) launched officially at the 2010 Washington meeting, a giant step toward the conquest of unexplored regions of the human genome has begun. IHEC aims at the production of 1,000 reference epigenomes to the international scientific community for next 7-10 years. Seven member institutions, including South Korea, Korea National Institute of Health (KNIH), will produce 25-200 reference epigenomes individually, and the produced data will be publically available by using a data center. Epigenome data will cover from whole genome bisulfite sequencing, histone modification, and chromatin access information to miRNA-seq. The final goal of IHEC is the production of reference maps of human epigenomes for key cellular status relevant to health and disease.
随着国际人类表观基因组联盟（IHEC）于2010年在华盛顿会议上正式启动，朝着攻克人类基因组未探索区域迈出了巨大一步。IHEC旨在在未来7至10年为国际科学界生成1000个参考表观基因组。包括韩国国立卫生研究院（KNIH）在内的七个成员机构将各自生成25至200个参考表观基因组，所产生的数据将通过数据中心公开提供。表观基因组数据将涵盖从全基因组亚硫酸氢盐测序、组蛋白修饰、染色质可及性信息到miRNA测序等内容。IHEC的最终目标是生成与健康和疾病相关的关键细胞状态的人类表观基因组参考图谱。
