Department of Otolaryngology-Head and Neck Surgery, Jiangsu Province Official Hospital, Nanjing, China.
PLoS One. 2013 Apr 17;8(4):e60313. doi: 10.1371/journal.pone.0060313. Print 2013.
Epstein-Barr virus (EBV) infection has been associated with lymphoma development. EBV latent membrane protein 1 (LMP1) is essential for EBV-mediated transformation and progression of different human cells, including lymphocytes. This meta-analysis investigated LMP1 expression with prognosis of patients with lymphoma.
The electronic databases of PubMed, Embase, and Chinese Biomedicine Databases were searched. There were 15 published studies available for a random effects model analysis. Quality assessment was performed using the Newcastle-Ottawa Quality Assessment Scale for cohort studies. A funnel plot was used to investigate publication bias, and sources of heterogeneity were identified by meta-regression analysis. The combined hazard ratios (HR) and their corresponding 95% confidence intervals of LMP1 expression were calculated by comparison to the overall survival.
Overall, there was no statistical significance found between LMP1 expression and survival of lymphoma patients (HR 1.25 [95% CI, 0.92-1.68]). In subgroup analyses, LMP1 expression was associated with survival in patients with non-Hodgkin lymphoma (NHL) (HR = 1.84, 95% CI: 1.02-3.34), but not with survival of patients with Hodgkin disease (HD) (HR = 1.03, 95% CI: 0.74-1.44). In addition, significant heterogeneity was present and the meta-regression revealed that the outcome of analysis was mainly influenced by the cutoff value.
This meta-analysis demonstrated that LMP1 expression appears to be an unfavorable prognostic factor for overall survival of NHL patients. The data suggested that EBV infection and LMP1 expression may be an important factor for NHL development or progression.
Epstein-Barr 病毒（EBV）感染与淋巴瘤的发展有关。EBV 潜伏膜蛋白 1（LMP1）是 EBV 介导的不同人类细胞（包括淋巴细胞）转化和进展所必需的。本荟萃分析研究了 LMP1 表达与淋巴瘤患者预后的关系。
检索了 PubMed、Embase 和中国生物医学文献数据库的电子数据库。有 15 项已发表的研究可用于随机效应模型分析。使用纽卡斯尔-渥太华质量评估量表对队列研究进行质量评估。使用漏斗图评估发表偏倚，并通过荟萃回归分析确定异质性的来源。通过与总生存率比较，计算 LMP1 表达的合并危险比（HR）及其相应的 95%置信区间。
总体而言，LMP1 表达与淋巴瘤患者的生存率之间没有统计学意义（HR 1.25 [95%CI，0.92-1.68]）。在亚组分析中，LMP1 表达与非霍奇金淋巴瘤（NHL）患者的生存率相关（HR = 1.84，95%CI：1.02-3.34），但与霍奇金病（HD）患者的生存率无关（HR = 1.03，95%CI：0.74-1.44）。此外，存在显著的异质性，荟萃回归显示分析结果主要受截止值的影响。
本荟萃分析表明，LMP1 表达似乎是 NHL 患者总体生存率的不利预后因素。数据表明，EBV 感染和 LMP1 表达可能是 NHL 发展或进展的重要因素。
