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诱导痰 MMP-1、-3 和 -8 浓度在结核病治疗期间的变化。

Induced sputum MMP-1, -3 & -8 concentrations during treatment of tuberculosis.

机构信息

Instituto de Medicina Tropical Alexander Von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Perú.

出版信息

PLoS One. 2013 Apr 22;8(4):e61333. doi: 10.1371/journal.pone.0061333. Print 2013.

DOI:10.1371/journal.pone.0061333
PMID:23613834
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3632571/
Abstract

INTRODUCTION

Tuberculosis (TB) destroys lung tissues and this immunopathology is mediated in part by Matrix Metalloproteinases (MMPs). There are no data on the relationship between local tissue MMPs concentrations, anti-tuberculosis therapy and sputum conversion.

MATERIALS AND METHODS

Induced sputum was collected from 68 TB patients and 69 controls in a cross-sectional study. MMPs concentrations were measured by Luminex array, TIMP concentrations by ELISA and were correlated with a disease severity score (TBscore). 46 TB patients were then studied longitudinally at the 2nd, 8th week and end of treatment.

RESULTS

Sputum MMP-1,-2,-3,-8,-9 and TIMP-1 and -2 concentrations are increased in TB. Elevated MMP-1 and -3 concentrations are independently associated with higher TB severity scores (p<0.05). MMP-1, -3 and -8 concentrations decreased rapidly during treatment (p<0.05) whilst there was a transient increase in TIMP-1/2 concentrations at week 2. MMP-2, -8 and -9 and TIMP-2 concentrations were higher at TB diagnosis in patients who remain sputum culture positive at 2 weeks and MMP-3, -8 and TIMP-1 concentrations were higher in these patients at 2nd week of TB treatment.

CONCLUSIONS

MMPs are elevated in TB patients and associate with disease severity. This matrix-degrading phenotype resolves rapidly with treatment. The MMP profile at presentation correlates with a delayed treatment response.

摘要

简介

肺结核（TB）会破坏肺部组织，这种免疫病理学部分是由基质金属蛋白酶（MMPs）介导的。目前尚无关于局部组织 MMP 浓度、抗结核治疗和痰转化之间关系的数据。

材料和方法

在一项横断面研究中，我们从 68 名肺结核患者和 69 名对照者中收集了诱导痰。通过 Luminex 阵列测量 MMPs 浓度，通过 ELISA 测量 TIMP 浓度，并与疾病严重程度评分（TBscore）相关联。然后对 46 名肺结核患者进行了纵向研究，在第 2、8 周和治疗结束时进行研究。

结果

肺结核患者的痰 MMP-1、-2、-3、-8、-9 和 TIMP-1、-2 浓度升高。升高的 MMP-1 和 -3 浓度与更高的 TB 严重程度评分独立相关（p<0.05）。MMP-1、-3 和 -8 浓度在治疗期间迅速下降（p<0.05），而 TIMP-1/2 浓度在第 2 周短暂升高。在第 2 周痰培养阳性的患者中，MMP-2、-8 和 -9 以及 TIMP-2 浓度在肺结核诊断时更高，而在这些患者中，MMP-3、-8 和 TIMP-1 浓度在第 2 周的肺结核治疗中更高。

结论

MMPs 在肺结核患者中升高，并与疾病严重程度相关。这种基质降解表型在治疗后迅速解决。发病时的 MMP 谱与治疗反应延迟相关。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f61/3632571/025fa0aa0597/pone.0061333.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f61/3632571/5c45cbe41412/pone.0061333.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f61/3632571/3084168d0b9d/pone.0061333.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f61/3632571/f6b4167ec8f8/pone.0061333.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f61/3632571/d45f7a9be5ff/pone.0061333.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f61/3632571/58528c263998/pone.0061333.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f61/3632571/ddb057a80831/pone.0061333.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f61/3632571/025fa0aa0597/pone.0061333.g007.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f61/3632571/5c45cbe41412/pone.0061333.g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f61/3632571/3084168d0b9d/pone.0061333.g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f61/3632571/f6b4167ec8f8/pone.0061333.g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f61/3632571/d45f7a9be5ff/pone.0061333.g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f61/3632571/58528c263998/pone.0061333.g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f61/3632571/ddb057a80831/pone.0061333.g006.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/9f61/3632571/025fa0aa0597/pone.0061333.g007.jpg

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