Department of Clinical Oncology, Toho University, 6-11-1 Omori-nishi, Ota-ku, Tokyo, 142-8541, Japan.
Department of Gastroenterological Surgery and Clinical Oncology, Graduate School of Medicine, Toho University, 6-11-1 Omori-nishi, Ota-ku, Tokyo, 142-8541, Japan.
Esophagus. 2022 Jan;19(1):105-112. doi: 10.1007/s10388-021-00866-6. Epub 2021 Aug 3.
Serum creatine kinase level has been reported to be a prognostic indicator in breast or lung cancers but no reports have been in esophageal cancer. We analyzed the prognostic significance of preoperative serum creatine kinase level in patients with esophageal carcinoma.
We evaluated the preoperative serum creatine kinase levels of 148 patients (118 male and 30 female) with esophageal squamous cell carcinoma. According to their median serum creatine kinase levels, we divided the patients into high and low serum creatine kinase groups. Univariate and multivariate analyses were used to evaluate the impact of serum creatine kinase level on the prognosis of the patients.
The tumor depth (P < 0.01) and stage (P < 0.01) were significantly associated with serum creatine kinase levels. The prognosis was worse in the low serum creatine kinase group than in the high serum creatine kinase group (P = 0.02). In the subgroup analysis, although no survival difference was observed in the female patients between the groups (P = 0.171), the survival of low serum creatine kinase group was significantly worse than that of high creatine kinase group in the male patients (P = 0.001). Cox proportional hazard regression analysis revealed that nodal status (P = 0.019) and serum creatine kinase level (P = 0.047) were independent risk factors associated with overall survival in the male patients.
Preoperative low serum creatine kinase level was useful in predicting overall survival in the male patients with esophageal squamous cell carcinoma.
血清肌酸激酶水平已被报道为乳腺癌或肺癌的预后指标，但尚无食管癌的相关报道。我们分析了术前血清肌酸激酶水平在食管癌患者中的预后意义。
我们评估了 148 例（男 118 例，女 30 例）食管鳞癌患者的术前血清肌酸激酶水平。根据中位数将患者分为高肌酸激酶组和低肌酸激酶组。采用单因素和多因素分析评估血清肌酸激酶水平对患者预后的影响。
肿瘤深度（P<0.01）和分期（P<0.01）与血清肌酸激酶水平显著相关。低肌酸激酶组的预后较肌酸激酶组差（P=0.02）。在亚组分析中，尽管两组女性患者的生存差异无统计学意义（P=0.171），但低肌酸激酶组男性患者的生存明显较肌酸激酶组差（P=0.001）。Cox 比例风险回归分析显示，淋巴结状态（P=0.019）和血清肌酸激酶水平（P=0.047）是男性患者总生存的独立危险因素。
术前低血清肌酸激酶水平可预测男性食管鳞癌患者的总生存。
