Department of Anesthesiology and Pain Medicine, School of Medicine, Chosun University, Gwangju, Korea.
Korean J Pain. 2013 Apr;26(2):125-9. doi: 10.3344/kjp.2013.26.2.125. Epub 2013 Apr 3.
5-hydroxytryptamine 3 (5-HT3) receptors have been known to be associated with the modulation of nociceptive transmission. However, it is uncertain whether 5-HT3 plays a role in the antinociceptive or pronociceptive pathway for incisional pain. In this study, we evaluated the effects of palonosetron, a 5-HT3 receptor antagonist, on incisional pain in rats when administered intrathecally or intraplantarly.
An intrathecal catheter was implanted through the cisterna magna and placed in the intrathecal space of rats. An incision in the plantaris muscle of the right hind paw was done under anesthesia with sevoflurane. Withdrawal thresholds were evaluated with the von Frey filament after 2 hours. Palonosetron (0.5 and 0.1 µg intrathecally; 0.5 µg intraplantarly) was administered and the thresholds were observed for 4 hours.
Mechanical hypersensitivity developed after the incision. Intrathecal palonosetron (0.5 µg and 0.1 µg) did not alter the paw withdrawal threshold. Intraplantar palonosetron (0.5 µg) also did not change the paw withdrawal threshold.
Intrathecal and intraplantar palonosetron (0.5 µg) had no effect on modulating the mechanical hypersensitivity in the incisional pain model of rats.
5-羟色胺 3（5-HT3）受体已被证实与伤害性感受传递的调节有关。然而，5-HT3 是否在切口痛的抗伤害或促伤害通路中发挥作用尚不确定。在这项研究中，我们评估了 5-HT3 受体拮抗剂帕洛诺司琼鞘内或足底给药对大鼠切口痛的影响。
通过枕骨大孔植入鞘内导管，并将其置于大鼠鞘内空间。在七氟醚麻醉下对右后爪的比目鱼肌进行切口。在 2 小时后使用冯弗雷尔细丝评估退缩阈值。鞘内给予帕洛诺司琼（0.5 和 0.1μg；0.5μg 足底内），并观察 4 小时的阈值。
切口后出现机械性过敏。鞘内帕洛诺司琼（0.5μg 和 0.1μg）不改变足底退缩阈值。足底内帕洛诺司琼（0.5μg）也不改变足底退缩阈值。
鞘内和足底给予帕洛诺司琼（0.5μg）对大鼠切口痛模型中的机械性过敏无影响。
