School of Aerospace, Mechanical and Manufacturing Engineering, RMIT University, Bundoora, VIC, Australia.
Inhal Toxicol. 2013 Apr;25(5):280-91. doi: 10.3109/08958378.2013.781250.
The inhalation exposure to airborne particles is investigated using a newly developed computational model that integrates the human respiratory airway with a human mannequin and at an enclosed room environment. Three free-stream air flow velocities (0.05, 0.20, and 0.35 m s⁻¹) that are in the range of occupational environments are used. Particles are released from different upstream locations and their trajectories are shown, which revealed that the trajectory paths of 80 μm particles that are inhaled are the same from the three different upstream planes evaluated. Smaller particles, 1 and 10 μm, exhibited different inhalation paths when released from different upstream distances. The free-stream velocity also has an effect on the particle trajectory particularly for larger particles. The aspiration efficiency for an extended range of particle sizes was evaluated. Reverse particle tracking matches the deposition in the respiratory airway with its initial particle source location. This can allow better risk assessments, and dosimetry determination due to inhalation exposure to contaminant sources.
采用一种新开发的计算模型，通过整合人体呼吸道模型与人体模型以及封闭的房间环境，对空气中颗粒的吸入暴露进行研究。模型中使用了三种自由流气流速度（0.05、0.20 和 0.35 m/s），这些速度处于职业环境范围内。从不同的上游位置释放颗粒，并显示它们的轨迹，结果表明，从三个不同的上游平面评估吸入的 80 μm 颗粒的轨迹路径是相同的。当从不同的上游距离释放时，1 和 10 μm 的较小颗粒表现出不同的吸入路径。自由流速度对较大颗粒的颗粒轨迹也有影响。评估了扩展粒径范围内的吸气效率。反向粒子跟踪将呼吸道的沉积与初始粒子源位置进行匹配。由于吸入污染物源的暴露，这可以更好地进行风险评估和剂量测定。
